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Table 3 The 34 significant pathways found by JEPETTO (Cytoscape plugin) with KEGG database

From: Network pharmacological identification of active compounds and potential actions of Erxian decoction in alleviating menopause-related symptoms

Pathway XD-score q value Overlap/size
Linoleic acid metabolism 3.148 0.000 10/11
Citrate cycle (TCA cycle) 3.057 0.000 21/26
Propanoate metabolism 1.899 0.000 11/19
Arachidonic acid metabolism 1.865 0.000 17/26
PPAR signaling pathway 1.794 0.000 22/39
Tyrosine metabolism 1.475 0.001 9/17
Retinol metabolism 1.474 0.009 6/12
Bladder cancer 1.463 0.000 17/38
Ether lipid metabolism 1.370 0.002 8/16
Metabolism of xenobiotics by cytochrome P450 1.313 0.001 10/20
Adipocytokine signaling pathway 1.248 0.000 24/57
Drug metabolism: cytochrome P450 1.240 0.003 8/17
Fatty acid metabolism 1.096 0.000 12/26
Pyruvate metabolism 1.096 0.000 12/26
One carbon pool by folate 1.057 0.018 5/10
Glyoxylate and dicarboxylate metabolism 1.057 0.018 5/10
Fc epsilon RI signaling pathway 1.040 0.000 23/65
Pancreatic cancer 1.013 0.000 25/70
Steroid hormone biosynthesis 0.990 0.027 6/15
GnRH signaling pathway 0.969 0.000 32/83
Beta-Alanine metabolism 0.924 0.007 7/15
Prostate cancer 0.913 0.000 32/84
Tryptophan metabolism 0.903 0.000 12/26
Long-term depression 0.893 0.000 23/57
Toll-like receptor signaling pathway 0.883 0.000 32/90
NOD-like receptor signaling pathway 0.879 0.000 21/59
Biosynthesis of unsaturated fatty acids 0.875 0.027 5/11
Riboflavin metabolism 0.875 0.027 5/11
VEGF signaling pathway 0.872 0.000 24/62
Glycerophospholipid metabolism 0.829 0.002 13/35
Type II diabetes mellitus 0.814 0.010 13/43
Chagas disease 0.804 0.000 36/99
Selenoamino acid metabolism 0.763 0.049 6/17
Renal cell carcinoma 0.708 0.000 24/68