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Table 4 Chemical–protein interactions and related significant signaling pathways

From: Network pharmacological identification of active compounds and potential actions of Erxian decoction in alleviating menopause-related symptoms

Herb

Compound

Protein

Pathway

HE

Emodin (1,3,8-trihydroxy-6-methylanthracene-9,10-dione)

HSD11B1

Steroid hormone biosynthesis

RMO

Alcool methylique

SULT2B1

Steroid hormone biosynthesis

CPC

Phenanthrene(TCMSP don’t record IUPAC name)

CYP1A1

Steroid hormone biosynthesis

RMO

Caffeic acid ((Z)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid)

COMT

Steroid hormone biosynthesis

HE

Quercetin(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one)

CYP19A1

Steroid hormone biosynthesis

HE

Quercetin-3-O-glucoside

CYP1B1

Steroid hormone biosynthesis

HE

Apigenin(5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one)

PTK2

VEGF signaling pathway

RMO

Hemo-sol((4R)-1-methyl-4-prop-1-en-2-ylcyclohexene)

HRAS

VEGF signaling pathway

HE/RA

Kaempferol(3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one)

MAPK1/AKT1/SRC

VEGF signaling pathway

RMO

Esculetin(6,7-dihydroxychromen-2-one)

MAPK3

VEGF signaling pathway

RMO

Citric acid(2-hydroxypropane-1,2,3-tricarboxylic acid)

KRAS

VEGF signaling pathway

HE

Oleanolic acid((3-beta)-3-Hydroxyolean-12-en-28-oic acid)

MAPK14

VEGF signaling pathway

RAS

Adenine(7H-purin-6-amine)

PTGS2

VEGF signaling pathway

HE

Emodin(1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione)

VEGFA

VEGF signaling pathway

HE

Luteolin(2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one)

PIK3CB

VEGF signaling pathway

RA

3,5,7-Trihydroxy-4′-methoxyl-8-prenylflavone-3-O-rhamnopyranoside

CASP9

VEGF signaling pathway

RC/RMO

Myristic acid

PPP3CB/PPP3CA

VEGF signaling pathway

RC/RMO/RAS

Palmitic acid

NOS3

VEGF signaling pathway

RAS

Lecithin

PLA2G4A

VEGF signaling pathway

HE/RMO

Lauric acid

PIK3CA

VEGF signaling pathway

RA

Chinoinin(1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one)

PLA2G2A

VEGF signaling pathway

RAS

4-Methoxybenzoic acid

PLA2G1B

VEGF signaling pathway

RMO

Nonanoic acid

NFAT5/NFATC3

VEGF signaling pathway

RMO

(9Z,12Z)-octadeca-9,12-dienoic acid

PLA2G10/PLA2G5

VEGF signaling pathway

RC/RMO

Myristic acid

PPP3CC

VEGF signaling pathway