Crude triterpenoid saponins from Ilex latifolia (Da Ye Dong Qing) ameliorate lipid accumulation by inhibiting SREBP expression via activation of AMPK in a non-alcoholic fatty liver disease model

Table 2 The chemical structures and contents of 12 triterpenoid saponins in the extract of I. latifolia

No.	Constituents	Structure							Experimental negative QTOF-MS (m/z)/error (ppm)	Weight of concentration (mg/g)
No.	Constituents	Type	R₁	R₂	R₃	R₄	R₅	=	Experimental negative QTOF-MS (m/z)/error (ppm)	Weight of concentration (mg/g)
1	Kudinoside O	A	S₄	OH	H	CH₃	S₂	12 (13)	1381.6641 [M − H]⁻/0.31	50.63
2	Kudinoside N	A	S₄	OH	CH₃	H	S₂	12 (13)	1381.6632 [M − H]⁻/0.96	3.45
3	Latifoloside H	A	S₃	OH	H	CH₃	S₂	12 (13)	1265.6165 [M + COOH]⁻/0.56	104.17
4	Latifoloside G	A	S₃	OH	CH₃	H	S₂	12 (13)	1265.6173 [M + COOH]⁻/−0.09	45.76
5	Kudinoside G	A	S₃	OH	CH₃	H	S₁	12 (13)	1119.5595 [M + COOH]⁻/−0.21	65.84
6	Kudinoside C	B	S₄	H	OH	–	–	13 (18)	1133.5375 [M + COOH]⁻/0.96	95.57
7	Kudinoside A	B	S₃	H	OH	–	–	13 (18)	971.4853 [M + COOH]⁻/0.45	117.97
8	Kudinoside E	B	S₄	H	H	–	–	11 (12), 13 (18)	1115.5287 [M + COOH]⁻/−0.68	78.31
9	Kudinoside F	B	S₃	OH	H	–	–	13 (18)	971.4848 [M + COOH]⁻/0.88	61.16
10	Latifoloside Q	A	S₃	H	H	CH₃	S₂	12 (13)	1249.6226 [M + COOH]⁻/−0.27	33.99
11	Kudinoside D	B	S₃	H	H	–	–	11 (12), 13 (18)	953.4759 [M + COOH]⁻/−0.82	196.68
12	Ilekudinoside G	B	S₄	H	H	–	–	12 (13)	1117.5430 [M + COOH]⁻/0.58	7.50
Crude triterpenoid saponins										861.03

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