Crude triterpenoid saponins from Ilex latifolia (Da Ye Dong Qing) ameliorate lipid accumulation by inhibiting SREBP expression via activation of AMPK in a non-alcoholic fatty liver disease model

Table 4 Effects of CTS on plasma parameters in mice fed with HFD

Parameter	Control	HFD	HFD + Simvastatin	HFD + CTS-100	HFD + CTS-200
TG (mmol/L)	1.37 ± 0.46	1.98 ± 0.54^#	1.04 ± 0.26^△△	1.29 ± 0.34**	1.21 ± 0.15**
TC (mmol/dL)	2.48 ± 0.23	6.27 ± 1.38^##	5.27 ± 0.20^△	5.79 ± 0.60	5.59 ± 0.70*
LDL-C (mmol/dL)	0.32 ± 0.19	2.80 ± 0.77^##	1.95 ± 0.45^△	2.53 ± 0.28	2.09 ± 0.39**
HDL-c (mmol/dL)	1.33 ± 0.46	0.95 ± 0.10^#	1.77 ± 0.66^△	1.25 ± 0.30**	1.36 ± 0.08**
Glucose (mmol/L)	8.61 ± 1.34	9.99 ± 1.56^##	8.76 ± 1.43^△	9.80 ± 1.53	9.60 ± 1.21
Insulin (nmol/L)	22.63 ± 5.93	36.56 ± 7.77^##	25.53 ± 7.03^△	26.43 ± 9.71*	24.52 ± 6.20**

Values were expressed as the mean ± SD (n = 10). ^# P < 0.05, ^## P < 0.01, HFD vs. control. ^△ P < 0.05,^△△ P < 0.01, HFD vs. simvastatin treatment. *P < 0.05, **P < 0.01, HFD vs. CTS treatment.

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