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Table 4 Effects of CTS on plasma parameters in mice fed with HFD

From: Crude triterpenoid saponins from Ilex latifolia (Da Ye Dong Qing) ameliorate lipid accumulation by inhibiting SREBP expression via activation of AMPK in a non-alcoholic fatty liver disease model

Parameter Control HFD HFD + Simvastatin HFD + CTS-100 HFD + CTS-200
TG (mmol/L) 1.37 ± 0.46 1.98 ± 0.54# 1.04 ± 0.26 1.29 ± 0.34** 1.21 ± 0.15**
TC (mmol/dL) 2.48 ± 0.23 6.27 ± 1.38## 5.27 ± 0.20 5.79 ± 0.60 5.59 ± 0.70*
LDL-C (mmol/dL) 0.32 ± 0.19 2.80 ± 0.77## 1.95 ± 0.45 2.53 ± 0.28 2.09 ± 0.39**
HDL-c (mmol/dL) 1.33 ± 0.46 0.95 ± 0.10# 1.77 ± 0.66 1.25 ± 0.30** 1.36 ± 0.08**
Glucose (mmol/L) 8.61 ± 1.34 9.99 ± 1.56## 8.76 ± 1.43 9.80 ± 1.53 9.60 ± 1.21
Insulin (nmol/L) 22.63 ± 5.93 36.56 ± 7.77## 25.53 ± 7.03 26.43 ± 9.71* 24.52 ± 6.20**
  1. Values were expressed as the mean ± SD (n = 10). # P < 0.05, ## P < 0.01, HFD vs. control. P < 0.05, P < 0.01, HFD vs. simvastatin treatment. *P < 0.05, **P < 0.01, HFD vs. CTS treatment.