Table 2 Comparisons of cytokine levels (pg/mL) by the BioPlex assay (mean ± SD)
From: Serum cytokine profiling analysis for zheng differentiation in chronic hepatitis B
Cytokines | LGDH (n = 20) | LKYD (n = 20) | HC (n = 20) | P value of (LGDH/LKYD) | P value of (CHB/HC) |
|---|---|---|---|---|---|
Group I | |||||
IL-1β | 2.5 ± 1.5 | 3.5 ± 1.5 | 3.4 ± 1.5 | 0.011 | 0.016 |
IL-1rα | 176.9 ± 129.7 | 246.3 ± 168.1 | 201.8 ± 159.8 | 0.065 | 0.188 |
IL-2 | BDR | BDR | BDR | BDR | – |
IL-4 | 3.1 ± 2.1 | 3.5 ± 2.0 | 3.9 ± 2.4 | 0.101 | 0.096 |
IL-5 | 3.9 ± 1.9 | 5.0 ± 1.7 | 4.4 ± 2.1 | 0.127 | 0.302 |
IL-6 | 9.9 ± 7.6 | 10.7 ± 8.2 | 8.2 ± 4.8 | 0.365 | 0.578 |
IL-7 | 15.6 ± 7.2 | 15.8 ± 5.9 | 16.0 ± 7.4 | 0.089 | 0.226 |
IL-8 | 30.5 ± 18.4 | 27.1 ± 13.2 | 48.8 ± 57.4 | 0.134 | 0.042 |
IL-9 | 62.8 ± 103.6 | 41.1 ± 83.3 | 8.3 ± 6.8 | 0.444 | 0.323 |
IL-10 | 10.6 ± 11.7 | 28.6 ± 92.7 | 8.8 ± 2.7 | 0.235 | 0.340 |
IL-12 (p70) | 21.5 ± 24.8 | 30.2 ± 50.9 | 18.6 ± 9.5 | 0.035 | 0.095 |
IL-13 | 12.8 ± 8.1 | 14.5 ± 7.2 | 13.1 ± 5.8 | 0.113 | 0.208 |
IL-15 | BDR | BDR | BDR | – | – |
IL-17 | 1.6 ± 2.9 | 4.8 ± 4.5 | 4.4 ± 3.9 | 0.006 | 0.007 |
Eotaxin | BDR | BDR | BDR | – | – |
FGF basic | 17.8 ± 12.8 | 22.3 ± 12.0 | 19.7 ± 9.3 | 0.019 | 0.040 |
G-CSF | BDR | BDR | BDR | – | – |
GM-CSF | 29.5 ± 32.9 | 29.0 ± 30.1 | 71.0 ± 35.2 | 0.107 | 0.003 |
IFN-γ | 133.4 ± 90.2 | 150.3 ± 86.8 | 141.1 ± 108.2 | 0.033 | 0.086 |
IP-10 | 820.7 ± 665.7 | 1,076.9 ± 733.4 | 408.9 ± 394.7 | 0.478 | 0.000 |
MCP-1 (MCAF) | 76.8 ± 46.2 | 70.3 ± 42.8 | 67.1 ± 35.4 | 0.496 | 0.755 |
MIP-1α | 5.3 ± 2.2 | 3.6 ± 2.0 | 5.2 ± 2.4 | 0.004 | 0.005 |
MIP-1β | 154.5 ± 70.4 | 230.9 ± 101.5 | 196.3 ± 149.5 | 0.026 | 0.064 |
PDGF-ββ | 6,536.6 ± 977.7 | 11,116.8 ± 1,731.4 | ADR | 0.054 | 0.008 |
RANTES | ADR | ADR | ADR | – | – |
TNF-α | 27.7 ± 21.5 | 26.7 ± 12.9 | 23.9 ± 12.1 | 0.026 | 0.110 |
VEGF | 115.7 ± 93.6 | 90.9 ± 53.1 | 158.6 ± 82.6 | 0.749 | 0.016 |
Group II | |||||
CTACK | 1063.6 ± 399.7 | 1059.6 ± 574.4 | 606.9 ± 269.0 | 0.728 | 0.002 |
GROα | BDR | BDR | BDR | – | – |
HGF | 940.1 ± 369.3 | 973.0 ± 424.8 | 776.9 ± 248.1 | 0.945 | 0.375 |
IFN-α2 | 145.7 ± 55.0 | 187.1 ± 49.2 | 181.9 ± 60.0 | 0.047 | 0.108 |
IL-1α | BDR | BDR | BDR | – | – |
IL-2Rα | 411.0 ± 297.1 | 414.6 ± 451.6 | 435.1 ± 431.0 | 0.945 | 0.565 |
IL-3 | BDR | BDR | BDR | – | – |
IL-12p40 | BDR | BDR | BDR | – | – |
IL-16 | 933.7 ± 784.2 | 968.0 ± 794.5 | 525.8 ± 335.6 | 0.627 | 0.146 |
IL-18 | 235.3 ± 99.6 | 309.7 ± 204.9 | 166.1 ± 90.1 | 0.513 | 0.022 |
LIF | 13.2 ± 16.2 | 15.6 ± 13.2 | 21.8 ± 12.2 | 0.089 | 0.046 |
MCP-3 | BDR | BDR | BDR | – | – |
M-CSF | BDR | BDR | BDR | – | – |
MIF | 679.2 ± 548.0 | 578.1 ± 422.1 | 587.3 ± 370.4 | 0.901 | 0.961 |
MIG | 1,255.3 ± 995.3 | 1,793.4 ± 1,382.2 | 900.4 ± 837.2 | 0.101 | 0.044 |
β-NGF | 2.6 ± 2.3 | 3.1 ± 2.1 | 4.8 ± 1.9 | 0.158 | 0.085 |
SCF | 215.9 ± 83.7 | 219.2 ± 82.9 | 143.7 ± 41.5 | 0.336 | 0.008 |
SCGF-β | 87,492.2 ± 33,886.1 | 90,081.1 ± 24,518.4 | 51,470.7 ± 14,275.2 | 0.065 | 0.002 |
SDF-1α | BDR | BDR | BDR | – | – |
TNF-β | BDR | BDR | BDR | – | – |
TRAIL | 209.5 ± 183.4 | 200.3 ± 143.4 | 213.0 ± 89.4 | 0.478 | 0.443 |