Skip to main content

Table 2 Comparisons of cytokine levels (pg/mL) by the BioPlex assay (mean ± SD)

From: Serum cytokine profiling analysis for zheng differentiation in chronic hepatitis B

Cytokines LGDH (n = 20) LKYD (n = 20) HC (n = 20) P value of (LGDH/LKYD) P value of (CHB/HC)
Group I
 IL-1β 2.5 ± 1.5 3.5 ± 1.5 3.4 ± 1.5 0.011 0.016
 IL-1rα 176.9 ± 129.7 246.3 ± 168.1 201.8 ± 159.8 0.065 0.188
 IL-2 BDR BDR BDR BDR
 IL-4 3.1 ± 2.1 3.5 ± 2.0 3.9 ± 2.4 0.101 0.096
 IL-5 3.9 ± 1.9 5.0 ± 1.7 4.4 ± 2.1 0.127 0.302
 IL-6 9.9 ± 7.6 10.7 ± 8.2 8.2 ± 4.8 0.365 0.578
 IL-7 15.6 ± 7.2 15.8 ± 5.9 16.0 ± 7.4 0.089 0.226
 IL-8 30.5 ± 18.4 27.1 ± 13.2 48.8 ± 57.4 0.134 0.042
 IL-9 62.8 ± 103.6 41.1 ± 83.3 8.3 ± 6.8 0.444 0.323
 IL-10 10.6 ± 11.7 28.6 ± 92.7 8.8 ± 2.7 0.235 0.340
 IL-12 (p70) 21.5 ± 24.8 30.2 ± 50.9 18.6 ± 9.5 0.035 0.095
 IL-13 12.8 ± 8.1 14.5 ± 7.2 13.1 ± 5.8 0.113 0.208
 IL-15 BDR BDR BDR
 IL-17 1.6 ± 2.9 4.8 ± 4.5 4.4 ± 3.9 0.006 0.007
 Eotaxin BDR BDR BDR
 FGF basic 17.8 ± 12.8 22.3 ± 12.0 19.7 ± 9.3 0.019 0.040
 G-CSF BDR BDR BDR
 GM-CSF 29.5 ± 32.9 29.0 ± 30.1 71.0 ± 35.2 0.107 0.003
 IFN-γ 133.4 ± 90.2 150.3 ± 86.8 141.1 ± 108.2 0.033 0.086
 IP-10 820.7 ± 665.7 1,076.9 ± 733.4 408.9 ± 394.7 0.478 0.000
 MCP-1 (MCAF) 76.8 ± 46.2 70.3 ± 42.8 67.1 ± 35.4 0.496 0.755
 MIP-1α 5.3 ± 2.2 3.6 ± 2.0 5.2 ± 2.4 0.004 0.005
 MIP-1β 154.5 ± 70.4 230.9 ± 101.5 196.3 ± 149.5 0.026 0.064
 PDGF-ββ 6,536.6 ± 977.7 11,116.8 ± 1,731.4 ADR 0.054 0.008
 RANTES ADR ADR ADR
 TNF-α 27.7 ± 21.5 26.7 ± 12.9 23.9 ± 12.1 0.026 0.110
 VEGF 115.7 ± 93.6 90.9 ± 53.1 158.6 ± 82.6 0.749 0.016
Group II
 CTACK 1063.6 ± 399.7 1059.6 ± 574.4 606.9 ± 269.0 0.728 0.002
 GROα BDR BDR BDR
 HGF 940.1 ± 369.3 973.0 ± 424.8 776.9 ± 248.1 0.945 0.375
 IFN-α2 145.7 ± 55.0 187.1 ± 49.2 181.9 ± 60.0 0.047 0.108
 IL-1α BDR BDR BDR
 IL-2Rα 411.0 ± 297.1 414.6 ± 451.6 435.1 ± 431.0 0.945 0.565
 IL-3 BDR BDR BDR
 IL-12p40 BDR BDR BDR
 IL-16 933.7 ± 784.2 968.0 ± 794.5 525.8 ± 335.6 0.627 0.146
 IL-18 235.3 ± 99.6 309.7 ± 204.9 166.1 ± 90.1 0.513 0.022
 LIF 13.2 ± 16.2 15.6 ± 13.2 21.8 ± 12.2 0.089 0.046
 MCP-3 BDR BDR BDR
 M-CSF BDR BDR BDR
 MIF 679.2 ± 548.0 578.1 ± 422.1 587.3 ± 370.4 0.901 0.961
 MIG 1,255.3 ± 995.3 1,793.4 ± 1,382.2 900.4 ± 837.2 0.101 0.044
 β-NGF 2.6 ± 2.3 3.1 ± 2.1 4.8 ± 1.9 0.158 0.085
 SCF 215.9 ± 83.7 219.2 ± 82.9 143.7 ± 41.5 0.336 0.008
 SCGF-β 87,492.2 ± 33,886.1 90,081.1 ± 24,518.4 51,470.7 ± 14,275.2 0.065 0.002
 SDF-1α BDR BDR BDR
 TNF-β BDR BDR BDR
 TRAIL 209.5 ± 183.4 200.3 ± 143.4 213.0 ± 89.4 0.478 0.443
  1. Significant P values are in italics (P < 0.05)
  2. BDR below the detection range and ADR above the detection range. Symbol “–”: Serum concentrations of IL-2, IL-15, Eotaxin, G-CSF, RANTES, GROα, IL-1α, IL-3, IL-12p40, MCP-3, M-CSF, SDF-1α, and TNF-β were beyond the detection range in both groups, thus there were no significant test result of these cytokines.