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Table 3 The targets identified

From: In silico target fishing and pharmacological profiling for the isoquinoline alkaloids of Macleaya cordata (Bo Luo Hui)

Targets Short name Type Pathway Diseases
Retinaldehyde-binding protein CRALBP Research Retinaldehyde metabolism Retinitis pigmentosa
Rhodopsin Opsin 2 Research Retina metabolism Retinitis pigmentosa
11-Beta-hydroxysteroid dehydrogenase HSD1 Successful Glucocorticoid concentration Diabetes
Osteoporosis
Hepatotoxicity
CAR/RXR heterodimer CAR/RXR Research Triglyceride metabolism Diabetes
Hepatitis
Aldose reductase ALR Successful Glucolipid metabolism Diabetes
Pain
Mineralocorticoid receptors MR Successful Na+/K+ equilibrium Inflammatory, autoimmune disease
Injury
Phosphodiesterase 4B PDE4B Successful AKT/mTOR pathway Cancer
Obesity
Phosphodiesterase 4D PDE4D Successful Intracellular cAMP//CREB signaling Cancer
Alzheimer’s
Protoporphyrinogen oxidase PPO Research Heme biosynthesis Cancer
Parasitosis
Transthyretin TTR Clinic Trial Thyroxine carrier Cancer
Alzheimer’s
Mitogen-activated protein kinase 10 JNK3 Research GbRH/ErbB/MAPK/insulin signaling pathway Cancer
Alzheimer’s
Sex hormone-binding globulin SHBG Research Sex steroids biosynthesis Cancer
NAD(P)H:quinone oxidoreductase NQO1 Research Quinones metabolism Cancer
Cellular retinol binding protein II CRBP2 Research Retinol metabolism Cancer
Estrogen receptor alphaa ERαa Successful Estrogen metabolism
Insulin-like growth factor pathway
Cancer
Alzheimer’s
Injury
Osteoporosis
Alpha-tocopherol (alpha-T) transfer protein ATTP Research α-Tocopherol metabolism Cancer
Human serum retinol binding protein 4 RBP4 Research Retinol metabolism Cancer
Estrogen receptor betaa ERβa Successful Estrogen metabolism
MAPK, PI3K signaling
Cancer
Alzheimer’s
Injury
Checkpoint kinase 1a Chk1a Research DNA damage response Cancer
Androgen receptor AR Successful Hormone metabolism Cancer
Reticulocyte 15S-lipoxygenase 15S-LOX Research Arachidonic acid metabolism Cancer
3-Phosphoinositide-dependent kinase-1a PDK-1a Research Phosphatidylinositol 3 kinase (PI3K) signaling Cancer
Casein kinase 2a CK2a Research Ser/Thr pathway Cancer
Cyclin dependent kinase 2a CDK2a Research Cell cycle Cancer
Calcium/calmodulin dependent protein kinase II delta CAMKII Research NF-κB-mediated inflammatory response
Ca2+-linked signaling
Cancer
Inflammatory, autoimmune disease
Dual-specificity protein kinase 1 CLK1 Research Nuclear redistribution of SR proteins Cancer
Proto-oncogene serine threonine kinasea PIM-1a Research Cell cycle regulation JAK/STAT pathway Cancer
Aurora kinase A Aurora-A Clinical trial Cell cycle arrest Cancer
Matrix metalloproteinases MMP12 Research Cell invasion, metastasis Cancer
Inflammatory, autoimmune disease
Phospholipase A2 PLA2s Successful VEGF/MAPK/GnRH signaling Cancer
Inflammatory, autoimmune disease
Mitogen-Activated Protein Kinases p38 MAPK p38 Clinical trial MAPK signaling Cancer
Pain
Inflammatory, autoimmune disease
Dermatosis
Tankyrase 2 Tankyrase 2 Research Canonical Wnt signaling Cancer
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Pi3Kγ Research Cancer migration, invasion
Inositol phosphate metabolism
Cancer
Inflammatory, autoimmune disease
PPARgamma-LBDa PPARγa Research LPS-induced iNOS expression Cancer
Inflammatory, autoimmune disease
Osteoporosis
Cartilage oligomeric matrix protein COMP Research Bone regeneration Autoimmune disease
Injury
Severe acute respiratory syndrome coronavirus (SARS-CoV) main protease (M(pro)) SARS M(pro) Research Virus maturation Virus infection
Glycosomal glyceraldehyde-3-Phosphate Dehydrogenase GAPDH Successful Glyceraldehydes metabolism Parasitosis
Glutathione disulfide oxidoreductase GR Research Glutathione metabolism Parasitosis
Acyl carrier protein reductasea PfENRa Successful Fatty acid biosynthesis Parasitosis
Acetylcholine binding protein alpha7 nAChR 7α Successful Calcium signaling pathway Alzheimer’s
Pain
3R-hydroxyacyl-acyl carrier protein dehydratase FabZ Research Fatty acid biosynthesis Parasitosis
Dihydroorotate dehydrogenase DHODH Successful Pyrimidine metabolism Parasitosis
TEM-1 Beta-Lactamasea TEM-1a Successful Cefotaxime metabolism Bacterial infection
Chloramphenicol acetyltransferase CAT Research Chloramphenicol metabolism Bacterial infection
Polyketide cyclase SnoaL SnoaL Research Nogalamycin biosynthesis Bacterial infection
ZipA attaches FtsZ protein ZipA-FtsZ Research Cell division Bacterial infection
Ferredoxin-NADP+ reductase FNR Successful Redox metabolism Bacterial infection
Polyketide cyclase AknH AknH Research Aclacinomycin biosynthesis Bacterial infection
Enoyl-acyl carrier protein reductase ENR Successful Fatty acid biosynthesis Bacterial infection
Multidrug binding protein TtgR TtgR Research Active extrusion of drug Bacterial infection
NmrA-like family domain NmrA Research Transcriptional repress Fungal infection
Bacterial phosphotriesterase opdA Research Organophosphate metabolism Bacterial infection
Streptomyces coelicolor TetR family protein ActRa ActRa Research Transcriptional repress Bacterial infection
Multidrug binding transcriptional regulator LmrR LmrR Research Autoregulatory mechanism Bacterial infection
Scytalone Dehydratase ScyD Research Fungicide Fungal infection
Human monoamine oxidase A MAO-A Successful Monoamines metabolism Depression
Acetylcholin esterase AChE Successful Glycerophospholipid metabolism Alzheimer’s
Parkinson’s
β-Site amyloid precursor protein cleaving enzyme BACE1 Clinical trial Neuregulin processing Alzheimer’s
Multidrug-resistant HIV-1 proteasea MDR HIV-1 proteasea Successful Self-activation AIDs
HIV-1 reverse transcriptase HIV-1 TR Successful ATP-dependent excision, pyrophosphorolysis AIDs
Oxysterol binding protein OSBP Research Intracellular lipid homeostasis
Signal conduction
Virus infection
Cancer
Rhodopsin Opsin 2 Research Rod photoreceptor Retinitis pigmentosa
Macrophage migration inhibitory factor MIF Clinical trial Phenylalanine, tyrosine metabolism Cancer
Inflammatory, autoimmune disease
Glycogen synthase kinase-3 beta GSK-3β Research Glycogen biosynthesis Cancer
Alzheimer’s
Diabetes
Hepatitis C virus (HCV) polymerase HS5B Pol Successful DNA biosynthesis Virus infection
  1. aThe targets verified by HypoDB screening