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Table 3 The targets identified

From: In silico target fishing and pharmacological profiling for the isoquinoline alkaloids of Macleaya cordata (Bo Luo Hui)

Targets

Short name

Type

Pathway

Diseases

Retinaldehyde-binding protein

CRALBP

Research

Retinaldehyde metabolism

Retinitis pigmentosa

Rhodopsin

Opsin 2

Research

Retina metabolism

Retinitis pigmentosa

11-Beta-hydroxysteroid dehydrogenase

HSD1

Successful

Glucocorticoid concentration

Diabetes

Osteoporosis

Hepatotoxicity

CAR/RXR heterodimer

CAR/RXR

Research

Triglyceride metabolism

Diabetes

Hepatitis

Aldose reductase

ALR

Successful

Glucolipid metabolism

Diabetes

Pain

Mineralocorticoid receptors

MR

Successful

Na+/K+ equilibrium

Inflammatory, autoimmune disease

Injury

Phosphodiesterase 4B

PDE4B

Successful

AKT/mTOR pathway

Cancer

Obesity

Phosphodiesterase 4D

PDE4D

Successful

Intracellular cAMP//CREB signaling

Cancer

Alzheimer’s

Protoporphyrinogen oxidase

PPO

Research

Heme biosynthesis

Cancer

Parasitosis

Transthyretin

TTR

Clinic Trial

Thyroxine carrier

Cancer

Alzheimer’s

Mitogen-activated protein kinase 10

JNK3

Research

GbRH/ErbB/MAPK/insulin signaling pathway

Cancer

Alzheimer’s

Sex hormone-binding globulin

SHBG

Research

Sex steroids biosynthesis

Cancer

NAD(P)H:quinone oxidoreductase

NQO1

Research

Quinones metabolism

Cancer

Cellular retinol binding protein II

CRBP2

Research

Retinol metabolism

Cancer

Estrogen receptor alphaa

ERαa

Successful

Estrogen metabolism

Insulin-like growth factor pathway

Cancer

Alzheimer’s

Injury

Osteoporosis

Alpha-tocopherol (alpha-T) transfer protein

ATTP

Research

α-Tocopherol metabolism

Cancer

Human serum retinol binding protein 4

RBP4

Research

Retinol metabolism

Cancer

Estrogen receptor betaa

ERβa

Successful

Estrogen metabolism

MAPK, PI3K signaling

Cancer

Alzheimer’s

Injury

Checkpoint kinase 1a

Chk1a

Research

DNA damage response

Cancer

Androgen receptor

AR

Successful

Hormone metabolism

Cancer

Reticulocyte 15S-lipoxygenase

15S-LOX

Research

Arachidonic acid metabolism

Cancer

3-Phosphoinositide-dependent kinase-1a

PDK-1a

Research

Phosphatidylinositol 3 kinase (PI3K) signaling

Cancer

Casein kinase 2a

CK2a

Research

Ser/Thr pathway

Cancer

Cyclin dependent kinase 2a

CDK2a

Research

Cell cycle

Cancer

Calcium/calmodulin dependent protein kinase II delta

CAMKII

Research

NF-κB-mediated inflammatory response

Ca2+-linked signaling

Cancer

Inflammatory, autoimmune disease

Dual-specificity protein kinase 1

CLK1

Research

Nuclear redistribution of SR proteins

Cancer

Proto-oncogene serine threonine kinasea

PIM-1a

Research

Cell cycle regulation JAK/STAT pathway

Cancer

Aurora kinase A

Aurora-A

Clinical trial

Cell cycle arrest

Cancer

Matrix metalloproteinases

MMP12

Research

Cell invasion, metastasis

Cancer

Inflammatory, autoimmune disease

Phospholipase A2

PLA2s

Successful

VEGF/MAPK/GnRH signaling

Cancer

Inflammatory, autoimmune disease

Mitogen-Activated Protein Kinases p38

MAPK p38

Clinical trial

MAPK signaling

Cancer

Pain

Inflammatory, autoimmune disease

Dermatosis

Tankyrase 2

Tankyrase 2

Research

Canonical Wnt signaling

Cancer

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Pi3Kγ

Research

Cancer migration, invasion

Inositol phosphate metabolism

Cancer

Inflammatory, autoimmune disease

PPARgamma-LBDa

PPARγa

Research

LPS-induced iNOS expression

Cancer

Inflammatory, autoimmune disease

Osteoporosis

Cartilage oligomeric matrix protein

COMP

Research

Bone regeneration

Autoimmune disease

Injury

Severe acute respiratory syndrome coronavirus (SARS-CoV) main protease (M(pro))

SARS M(pro)

Research

Virus maturation

Virus infection

Glycosomal glyceraldehyde-3-Phosphate Dehydrogenase

GAPDH

Successful

Glyceraldehydes metabolism

Parasitosis

Glutathione disulfide oxidoreductase

GR

Research

Glutathione metabolism

Parasitosis

Acyl carrier protein reductasea

PfENRa

Successful

Fatty acid biosynthesis

Parasitosis

Acetylcholine binding protein alpha7

nAChR 7α

Successful

Calcium signaling pathway

Alzheimer’s

Pain

3R-hydroxyacyl-acyl carrier protein dehydratase

FabZ

Research

Fatty acid biosynthesis

Parasitosis

Dihydroorotate dehydrogenase

DHODH

Successful

Pyrimidine metabolism

Parasitosis

TEM-1 Beta-Lactamasea

TEM-1a

Successful

Cefotaxime metabolism

Bacterial infection

Chloramphenicol acetyltransferase

CAT

Research

Chloramphenicol metabolism

Bacterial infection

Polyketide cyclase SnoaL

SnoaL

Research

Nogalamycin biosynthesis

Bacterial infection

ZipA attaches FtsZ protein

ZipA-FtsZ

Research

Cell division

Bacterial infection

Ferredoxin-NADP+ reductase

FNR

Successful

Redox metabolism

Bacterial infection

Polyketide cyclase AknH

AknH

Research

Aclacinomycin biosynthesis

Bacterial infection

Enoyl-acyl carrier protein reductase

ENR

Successful

Fatty acid biosynthesis

Bacterial infection

Multidrug binding protein TtgR

TtgR

Research

Active extrusion of drug

Bacterial infection

NmrA-like family domain

NmrA

Research

Transcriptional repress

Fungal infection

Bacterial phosphotriesterase

opdA

Research

Organophosphate metabolism

Bacterial infection

Streptomyces coelicolor TetR family protein ActRa

ActRa

Research

Transcriptional repress

Bacterial infection

Multidrug binding transcriptional regulator LmrR

LmrR

Research

Autoregulatory mechanism

Bacterial infection

Scytalone Dehydratase

ScyD

Research

Fungicide

Fungal infection

Human monoamine oxidase A

MAO-A

Successful

Monoamines metabolism

Depression

Acetylcholin esterase

AChE

Successful

Glycerophospholipid metabolism

Alzheimer’s

Parkinson’s

β-Site amyloid precursor protein cleaving enzyme

BACE1

Clinical trial

Neuregulin processing

Alzheimer’s

Multidrug-resistant HIV-1 proteasea

MDR HIV-1 proteasea

Successful

Self-activation

AIDs

HIV-1 reverse transcriptase

HIV-1 TR

Successful

ATP-dependent excision, pyrophosphorolysis

AIDs

Oxysterol binding protein

OSBP

Research

Intracellular lipid homeostasis

Signal conduction

Virus infection

Cancer

Rhodopsin

Opsin 2

Research

Rod photoreceptor

Retinitis pigmentosa

Macrophage migration inhibitory factor

MIF

Clinical trial

Phenylalanine, tyrosine metabolism

Cancer

Inflammatory, autoimmune disease

Glycogen synthase kinase-3 beta

GSK-3β

Research

Glycogen biosynthesis

Cancer

Alzheimer’s

Diabetes

Hepatitis C virus (HCV) polymerase

HS5B Pol

Successful

DNA biosynthesis

Virus infection

  1. aThe targets verified by HypoDB screening