Targets | Short name | Type | Pathway | Diseases |
---|---|---|---|---|
Retinaldehyde-binding protein | CRALBP | Research | Retinaldehyde metabolism | Retinitis pigmentosa |
Rhodopsin | Opsin 2 | Research | Retina metabolism | Retinitis pigmentosa |
11-Beta-hydroxysteroid dehydrogenase | HSD1 | Successful | Glucocorticoid concentration | Diabetes Osteoporosis Hepatotoxicity |
CAR/RXR heterodimer | CAR/RXR | Research | Triglyceride metabolism | Diabetes Hepatitis |
Aldose reductase | ALR | Successful | Glucolipid metabolism | Diabetes Pain |
Mineralocorticoid receptors | MR | Successful | Na+/K+ equilibrium | Inflammatory, autoimmune disease Injury |
Phosphodiesterase 4B | PDE4B | Successful | AKT/mTOR pathway | Cancer Obesity |
Phosphodiesterase 4D | PDE4D | Successful | Intracellular cAMP//CREB signaling | Cancer Alzheimer’s |
Protoporphyrinogen oxidase | PPO | Research | Heme biosynthesis | Cancer Parasitosis |
Transthyretin | TTR | Clinic Trial | Thyroxine carrier | Cancer Alzheimer’s |
Mitogen-activated protein kinase 10 | JNK3 | Research | GbRH/ErbB/MAPK/insulin signaling pathway | Cancer Alzheimer’s |
Sex hormone-binding globulin | SHBG | Research | Sex steroids biosynthesis | Cancer |
NAD(P)H:quinone oxidoreductase | NQO1 | Research | Quinones metabolism | Cancer |
Cellular retinol binding protein II | CRBP2 | Research | Retinol metabolism | Cancer |
Estrogen receptor alphaa | ERαa | Successful | Estrogen metabolism Insulin-like growth factor pathway | Cancer Alzheimer’s Injury Osteoporosis |
Alpha-tocopherol (alpha-T) transfer protein | ATTP | Research | α-Tocopherol metabolism | Cancer |
Human serum retinol binding protein 4 | RBP4 | Research | Retinol metabolism | Cancer |
Estrogen receptor betaa | ERβa | Successful | Estrogen metabolism MAPK, PI3K signaling | Cancer Alzheimer’s Injury |
Checkpoint kinase 1a | Chk1a | Research | DNA damage response | Cancer |
Androgen receptor | AR | Successful | Hormone metabolism | Cancer |
Reticulocyte 15S-lipoxygenase | 15S-LOX | Research | Arachidonic acid metabolism | Cancer |
3-Phosphoinositide-dependent kinase-1a | PDK-1a | Research | Phosphatidylinositol 3 kinase (PI3K) signaling | Cancer |
Casein kinase 2a | CK2a | Research | Ser/Thr pathway | Cancer |
Cyclin dependent kinase 2a | CDK2a | Research | Cell cycle | Cancer |
Calcium/calmodulin dependent protein kinase II delta | CAMKII | Research | NF-κB-mediated inflammatory response Ca2+-linked signaling | Cancer Inflammatory, autoimmune disease |
Dual-specificity protein kinase 1 | CLK1 | Research | Nuclear redistribution of SR proteins | Cancer |
Proto-oncogene serine threonine kinasea | PIM-1a | Research | Cell cycle regulation JAK/STAT pathway | Cancer |
Aurora kinase A | Aurora-A | Clinical trial | Cell cycle arrest | Cancer |
Matrix metalloproteinases | MMP12 | Research | Cell invasion, metastasis | Cancer Inflammatory, autoimmune disease |
Phospholipase A2 | PLA2s | Successful | VEGF/MAPK/GnRH signaling | Cancer Inflammatory, autoimmune disease |
Mitogen-Activated Protein Kinases p38 | MAPK p38 | Clinical trial | MAPK signaling | Cancer Pain Inflammatory, autoimmune disease Dermatosis |
Tankyrase 2 | Tankyrase 2 | Research | Canonical Wnt signaling | Cancer |
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Pi3Kγ | Research | Cancer migration, invasion Inositol phosphate metabolism | Cancer Inflammatory, autoimmune disease |
PPARgamma-LBDa | PPARγa | Research | LPS-induced iNOS expression | Cancer Inflammatory, autoimmune disease Osteoporosis |
Cartilage oligomeric matrix protein | COMP | Research | Bone regeneration | Autoimmune disease Injury |
Severe acute respiratory syndrome coronavirus (SARS-CoV) main protease (M(pro)) | SARS M(pro) | Research | Virus maturation | Virus infection |
Glycosomal glyceraldehyde-3-Phosphate Dehydrogenase | GAPDH | Successful | Glyceraldehydes metabolism | Parasitosis |
Glutathione disulfide oxidoreductase | GR | Research | Glutathione metabolism | Parasitosis |
Acyl carrier protein reductasea | PfENRa | Successful | Fatty acid biosynthesis | Parasitosis |
Acetylcholine binding protein alpha7 | nAChR 7α | Successful | Calcium signaling pathway | Alzheimer’s Pain |
3R-hydroxyacyl-acyl carrier protein dehydratase | FabZ | Research | Fatty acid biosynthesis | Parasitosis |
Dihydroorotate dehydrogenase | DHODH | Successful | Pyrimidine metabolism | Parasitosis |
TEM-1 Beta-Lactamasea | TEM-1a | Successful | Cefotaxime metabolism | Bacterial infection |
Chloramphenicol acetyltransferase | CAT | Research | Chloramphenicol metabolism | Bacterial infection |
Polyketide cyclase SnoaL | SnoaL | Research | Nogalamycin biosynthesis | Bacterial infection |
ZipA attaches FtsZ protein | ZipA-FtsZ | Research | Cell division | Bacterial infection |
Ferredoxin-NADP+ reductase | FNR | Successful | Redox metabolism | Bacterial infection |
Polyketide cyclase AknH | AknH | Research | Aclacinomycin biosynthesis | Bacterial infection |
Enoyl-acyl carrier protein reductase | ENR | Successful | Fatty acid biosynthesis | Bacterial infection |
Multidrug binding protein TtgR | TtgR | Research | Active extrusion of drug | Bacterial infection |
NmrA-like family domain | NmrA | Research | Transcriptional repress | Fungal infection |
Bacterial phosphotriesterase | opdA | Research | Organophosphate metabolism | Bacterial infection |
Streptomyces coelicolor TetR family protein ActRa | ActRa | Research | Transcriptional repress | Bacterial infection |
Multidrug binding transcriptional regulator LmrR | LmrR | Research | Autoregulatory mechanism | Bacterial infection |
Scytalone Dehydratase | ScyD | Research | Fungicide | Fungal infection |
Human monoamine oxidase A | MAO-A | Successful | Monoamines metabolism | Depression |
Acetylcholin esterase | AChE | Successful | Glycerophospholipid metabolism | Alzheimer’s Parkinson’s |
β-Site amyloid precursor protein cleaving enzyme | BACE1 | Clinical trial | Neuregulin processing | Alzheimer’s |
Multidrug-resistant HIV-1 proteasea | MDR HIV-1 proteasea | Successful | Self-activation | AIDs |
HIV-1 reverse transcriptase | HIV-1 TR | Successful | ATP-dependent excision, pyrophosphorolysis | AIDs |
Oxysterol binding protein | OSBP | Research | Intracellular lipid homeostasis Signal conduction | Virus infection Cancer |
Rhodopsin | Opsin 2 | Research | Rod photoreceptor | Retinitis pigmentosa |
Macrophage migration inhibitory factor | MIF | Clinical trial | Phenylalanine, tyrosine metabolism | Cancer Inflammatory, autoimmune disease |
Glycogen synthase kinase-3 beta | GSK-3β | Research | Glycogen biosynthesis | Cancer Alzheimer’s Diabetes |
Hepatitis C virus (HCV) polymerase | HS5B Pol | Successful | DNA biosynthesis | Virus infection |