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Table 4 Summary of co-occurrence patterns that have CM syndrome connotations

From: Identification of Chinese medicine syndromes in persistent insomnia associated with major depressive disorder: a latent tree analysis

Latent states Co-occurrence patterns Relevant CM syndromes
Y18 = s1 Thirst, favor of drinking Liver-qi stagnation transforming into fire
Y17 = s1 Dry mouth, dry throat, bitter taste, agitation Liver fire flaming upward, Stomach disharmony
Hyperactivity of fire due to yin deficiency
Y16 = s1 Weary limbs, sore knees, hypochondriac pain, backache, pain in the chest and hypochondrium, aphthous stomatitis Deficiency of both the heart and spleen
Liver fire flaming upward
Heart-kidney noninteraction
Y15 = s1 Heavy headedness, head distension, difficulty falling asleep alone Internal disturbance of phlegm-heat
Liver-qi stagnation transforming into fire
Qi deficiency of the heart and gallbladder
Y14 = s1 Insomnia with vexation, vexation, restless sleep, vexation in sitting and lying down Qi deficiency of the heart and gallbladder
Stomach disharmony
Heart-kidney noninteraction.
Y13 = s1 Sleeping late at night, frequent awakening with a start, half asleep, poor memory Liver fire flaming upward
Deficiency of both the heart and spleen
Heart-kidney noninteraction
Y12 = s1 Headache, excessive dreaming, night sweating, feverish sensations in the palms, soles and chest, tinnitus. Liver fire flaming upward
Y11 = s1 Nausea, poor appetite Internal disturbance of phlegm-heat
Y10 = s1 Lassitude, fright palpitation, dyspnea, tasteless, oppression in the chest, cold extremities Heart-kidney noninteraction,
Heart deficiency with timidity
Y09 = s1 Frequent sighing, fatigue, vexation, unrefreshing sleep, dizziness, difficulty falling asleep with vexation, palpitation. Liver-qi stagnation transforming into fire
Stomach disharmony
Liver fire flaming upward
Heart-kidney noninteraction
Y08 = s1 Thoughtful Qi deficiency of the heart and gallbladder
Y07 = s1 Impatience, irritability Liver-qi stagnation transforming into fire
Liver fire flaming upward
Heart-kidney noninteraction
Y05 = s1 Belching, gastric stuffiness, stuffiness and pain in stomach and abdomen, stuffiness in stomach and abdomen, profuse sputum, difficulty falling asleep, hypochondriac distension Stomach disharmony
Y04 = s1 Acid regurgitation, insomnia Internal disturbance of phlegm-heat
Hyperactivity of fire due to yin deficiency