Fig. 6
From: Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro
Non-linear regression and double reciprocal (Lineweaver–Burk) plots for direct inhibition of midazolam 1-hydroxylation by different concentrations of STS (0–100 μM) in HLM incubations (0.5 mg protein/mL). The inhibition of CYP3A4 activity by STS can be best-described as full competitive inhibition. Each data point is the mean of triple incubations