Table 1 Demographic and medication characteristics and results of multiple logistic regression for CM use among patients with Alzheimer’s disease
From: Patterns of Chinese medicine use in prescriptions for treating Alzheimer’s disease in Taiwan
Characteristics | CMa users | CMa non-users | aORb (95 % CIc) |
|---|---|---|---|
No. of cases | 889 (78.2 %) | 248 (21.8 %) | |
Age at diagnosis (incidence rate) | |||
<45 (0.001 %) | 7 (0.8 %) | 2 (0.8 %) | 0.78 (0.15–4.05) |
45–54 (0.036 %) | 27 (3 %) | 2 (0.8 %) | 3.64 (0.80–16.53) |
55–64 (0.246 %) | 115 (12.9 %) | 27 (10.9 %) | 1 |
65–74 (1.185 %) | 309 (34.8 %) | 92 (37.1 %) | 0.74 (0.45–1.22) |
75–84 (7.105 %) | 381 (42.9 %) | 107 (43.1 %) | 0.83 (0.51–1.36) |
≥85 (17.942 %) | 50 (5.6 %) | 18 (7.3 %) | 0.61 (0.30–1.24) |
Mean years | 72.8 | 73.8 | |
Sex | |||
Female (0.13 %) | 530 (59.6 %) | 121(48.8 %) | 1.57 (1.16–2.13) |
Male (0.10 %) | 359 (40.4 %) | 127 (51.2 %) | 1 |
Insured region | |||
Taipei city | 137 (15.4 %) | 61 (24.6 %) | 1 |
Kaohsiung city | 71 (8 %) | 14 (5.6 %) | 2.38 (1.24–4.57) |
Northern Taiwan | 200 (22.5 %) | 58 (23.4 %) | 1.65 (1.07–2.54) |
Middle Taiwan | 209 (23.5 %) | 32 (12.9 %) | 3.00 (1.83–4.90) |
Southern Taiwan | 240 (27 %) | 78 (31.5 %) | 1.39 (0.91–2.12) |
Eastern Taiwan | 21 (2.4 %) | 4 (1.6 %) | 2.48 (0.80–7.64) |
Outlying island | 11 (1.2 %) | 1 (0.4 %) | 4.98 (0.61–40.51) |
Insured amount (NT$d) | |||
0 | 353 (39.7 %) | 94 (37.9 %) | 0.99 (0.68–1.45) |
1–19,999 | 486 (54.7 %) | 140 (56.5 %) | 1 |
20,000–39,999 | 32 (3.6 %) | 8 (3.2 %) | 0.90 (0.38–2.15) |
≥400,000 | 18 (2 %) | 6 (2.4 %) | 0.77 (0.28–2.13) |
Numbers of anti-Alzheimer’s or BPSD drugs | |||
1 | 28 (3.1 %) | 8 (3.2 %) | 1 |
2 | 145 (16.3 %) | 51 (20.6 %) | 0.81 (0.35–1.90) |
3 | 318 (35.8 %) | 87 (35.1 %) | 1.04 (0.46–2.37) |
≥4 | 398 (44.8 %) | 102 (41.1 %) | 1.12 (0.49–2.52) |
Numbers of dementia BPSDe | |||
0 | 102 (11.5 %) | 46 (18.5 %) | 1 |
1 | 122 (13.7 %) | 61 (24.6 %) | 0.90 (0.57–1.44) |
Delirium | 4 | 3 | |
Delusions | 13 | 7 | |
Depression | 18 | 12 | |
Behavioral disturbance | 4 | 2 | |
Sleep disturbances | 83 | 37 | |
Hallucination | 0 | 0 | |
2 | 250 (28.1 %) | 58 (23.4 %) | 1.94 (1.24–3.05) |
Delirium + delusions | 8 | 7 | |
Delirium + depression | 2 | 1 | |
Delirium + behavioral | 0 | 0 | |
Delirium + sleep | 12 | 6 | |
Delirium + hallucination | 0 | 0 | |
Delusions + depression | 10 | 6 | |
Delusions + behavioral | 0 | 0 | |
Delusions + sleep | 21 | 11 | |
Delusions + hallucination | 0 | 0 | |
Depression + behavioral | 1 | 0 | |
Depression + sleep | 21 | 8 | |
Depression + hallucination | 0 | 1 | |
Behavioral + sleep | 6 | 0 | |
Behavioral + hallucination | 0 | 0 | |
Sleep + hallucination | 169 | 22 | |
≥3 | 415 (46.7 %) | 83 (33.5 %) | 2.26 (1.48–3.43) |
Numbers of comorbidity | |||
0 | 25 (2.81 %) | 10 (4.03 %) | 1 |
1 | 74 (8.32 %) | 27 (10.89 %) | 1.1 (0.47–2.58) |
2 | 148 (16.7 %) | 65 (26.21 %) | 0.91 (0.41–2.01) |
≥3 | 642 (72.2 %) | 146 (58.87 %) | 1.76 (0.83–3.74) |