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Table 1 Demographic and medication characteristics and results of multiple logistic regression for CM use among patients with Alzheimer’s disease

From: Patterns of Chinese medicine use in prescriptions for treating Alzheimer’s disease in Taiwan

Characteristics CMa users CMa non-users aORb (95 % CIc)
No. of cases 889 (78.2 %) 248 (21.8 %)  
Age at diagnosis (incidence rate)
 <45 (0.001 %) 7 (0.8 %) 2 (0.8 %) 0.78 (0.15–4.05)
 45–54 (0.036 %) 27 (3 %) 2 (0.8 %) 3.64 (0.80–16.53)
 55–64 (0.246 %) 115 (12.9 %) 27 (10.9 %) 1
 65–74 (1.185 %) 309 (34.8 %) 92 (37.1 %) 0.74 (0.45–1.22)
 75–84 (7.105 %) 381 (42.9 %) 107 (43.1 %) 0.83 (0.51–1.36)
 ≥85 (17.942 %) 50 (5.6 %) 18 (7.3 %) 0.61 (0.30–1.24)
Mean years 72.8 73.8  
Sex
 Female (0.13 %) 530 (59.6 %) 121(48.8 %) 1.57 (1.16–2.13)
 Male (0.10 %) 359 (40.4 %) 127 (51.2 %) 1
Insured region
 Taipei city 137 (15.4 %) 61 (24.6 %) 1
 Kaohsiung city 71 (8 %) 14 (5.6 %) 2.38 (1.24–4.57)
 Northern Taiwan 200 (22.5 %) 58 (23.4 %) 1.65 (1.07–2.54)
 Middle Taiwan 209 (23.5 %) 32 (12.9 %) 3.00 (1.83–4.90)
 Southern Taiwan 240 (27 %) 78 (31.5 %) 1.39 (0.91–2.12)
 Eastern Taiwan 21 (2.4 %) 4 (1.6 %) 2.48 (0.80–7.64)
 Outlying island 11 (1.2 %) 1 (0.4 %) 4.98 (0.61–40.51)
Insured amount (NT$d)    
 0 353 (39.7 %) 94 (37.9 %) 0.99 (0.68–1.45)
 1–19,999 486 (54.7 %) 140 (56.5 %) 1
 20,000–39,999 32 (3.6 %) 8 (3.2 %) 0.90 (0.38–2.15)
 ≥400,000 18 (2 %) 6 (2.4 %) 0.77 (0.28–2.13)
Numbers of anti-Alzheimer’s or BPSD drugs
 1 28 (3.1 %) 8 (3.2 %) 1
 2 145 (16.3 %) 51 (20.6 %) 0.81 (0.35–1.90)
 3 318 (35.8 %) 87 (35.1 %) 1.04 (0.46–2.37)
 ≥4 398 (44.8 %) 102 (41.1 %) 1.12 (0.49–2.52)
Numbers of dementia BPSDe
 0 102 (11.5 %) 46 (18.5 %) 1
 1 122 (13.7 %) 61 (24.6 %) 0.90 (0.57–1.44)
  Delirium 4 3  
  Delusions 13 7  
  Depression 18 12  
  Behavioral disturbance 4 2  
  Sleep disturbances 83 37  
  Hallucination 0 0  
 2 250 (28.1 %) 58 (23.4 %) 1.94 (1.24–3.05)
  Delirium + delusions 8 7  
  Delirium + depression 2 1  
  Delirium + behavioral 0 0  
  Delirium + sleep 12 6  
  Delirium + hallucination 0 0  
  Delusions + depression 10 6  
  Delusions + behavioral 0 0  
  Delusions + sleep 21 11  
  Delusions + hallucination 0 0  
  Depression + behavioral 1 0  
  Depression + sleep 21 8  
  Depression + hallucination 0 1  
  Behavioral + sleep 6 0  
  Behavioral + hallucination 0 0  
  Sleep + hallucination 169 22  
 ≥3 415 (46.7 %) 83 (33.5 %) 2.26 (1.48–3.43)
Numbers of comorbidity
 0 25 (2.81 %) 10 (4.03 %) 1
 1 74 (8.32 %) 27 (10.89 %) 1.1 (0.47–2.58)
 2 148 (16.7 %) 65 (26.21 %) 0.91 (0.41–2.01)
 ≥3 642 (72.2 %) 146 (58.87 %) 1.76 (0.83–3.74)
  1. a CM refers to Chinese medicine
  2. b aOR refers to adjust odds ratio
  3. c CI refers to confidence interval
  4. d NT$ refers to new Taiwan dollars, of which 1 US $ = 30 NT$
  5. e BPSD refers to behavioral and psychological symptoms of dementia