Fig. 5

Characterization of CD4⁺CD25⁺Foxp3⁺ Tregs and IL-10 + Bregs in LZ–SMS or PBS-treated MRL/lpr and Balb/c mice. Bar charts show the arithmetic mean plus SD of the percentages of CD4⁺CD25⁺Foxp3⁺ Tregs in a splenic, b thymic and c peripheral blood cells; and the ratios of CD4⁺CD25⁺Foxp3⁺ Treg %/CD4⁺CD25⁻ effector T cell % in d splenic, e thymic and f peripheral blood cells; and the percentages of IL-10 + Breg cells in g splenic, h thymic and i peripheral blood cells. *P < 0.05, **P < 0.01, ***P < 0.001, LZ–SMS vs. PBS treatment; ^& P < 0.05, ^&& P < 0.01, ^&&& P < 0.001, Balb/c control mice vs. PBS-treated MRL/lpr mice; ^# P < 0.05, ^## P < 0.01, ^### P < 0.001, Balb/c control mice vs. LZ–SMS-treated MRL/lpr mice (n = 5 in each group)