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Table 1 Clinical characteristics of MRL/lpr and Balb/c mice before treatment

From: Anti-inflammatory activities of Ganoderma lucidum (Lingzhi) and San-Miao-San supplements in MRL/lpr mice for the treatment of systemic lupus erythematosus

  MRL/lpr (n = 30) Balb/c
Mild (n = 10) Moderate (n = 10) Severe (n = 10) Normal (n = 10)
Clinical assessment
Body weight, mean ± SD, g 48.0 ± 8.7& 49.4 ± 9.1** 48.7 ± 4.1# 19.2 ± 0.2
Joint thickness, mean ± SD, μm 84.3 ± 3.1 84.7 ± 2.7* 84.4 ± 2.4 79.3 ± 3.6
Lupus flare score, mean ± SD 0.7 ± 0.5 1.0 ± 0.9 1.3 ± 1.0# 0
Proteinuria score, mean ± SD 1.5 ± 0.5 2.8 ± 0.4*** 4.0 ± 1.1### 0.7 ± 0.6
Leukocyturia score, mean ± SD 0.5 ± 1.2 2.0 ± 1.4* 2.5 ± 0.5## 0
Lymphadenopathy, No. (%) 10/10 (100 %)&&& 10/10 (100 %)*** 10/10 (100 %)### 0/10 (0 %)
  1. Joint thickness was measured in three joints of each hind paw (tarsus joint); Leukocyturia score was determined by a four-point scale (0–3, where 0 was normal and 3 was severe); No. (%), percentages of mice had lymphadenopathy among each group
  2. SD standard deviation, MRL/lpr MRL/MpJ-Faslpr/2 J, Mild mice with mild disease activity (mild SLE, proteinuria score is 0–1), Moderate moderate disease activity (moderate SLE, proteinuria score is 2–3), Severe high disease activity (severe SLE, proteinuria score is 4–5), Normal age- and sex- matched healthy Balb/c mice
  3. & P = 0.03, && P = 0.008, &&& P = 0.0008, comparing between control and mild SLE mice
  4. * P = 0.03, ** P = 0.008, *** P = 0.0008, comparing between control and moderate SLE mice
  5. # P = 0.03, ## P = 0.008, ###  P = 0.0008, comparing between control and severe SLE mice