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Table 2 Th differentiation PCR array analysis

From: Anti-inflammatory activities of Ganoderma lucidum (Lingzhi) and San-Miao-San supplements in MRL/lpr mice for the treatment of systemic lupus erythematosus

Transcription Factors

Cytokines and receptors

Gene

LZ–SMS PBS

Gene

LZ–SMS PBS

Fosl1

1.94

Tnf

0.98

Nr4a1

5.12

Il1r2

1.94

Nr4a3

6.46

Il17re

1.10

Hoxa10

1.06

Il21

2.01

Rel

3.22

Ccr6

1.11

Irf4

2.03

Csf2

0.79

Nfatc1

1.88

Il4

1.12

Irf8

1.57

Il18r1

1.78

Id2

1.74

Ccr3

3.61

Gata4

1.99

Ccl5

0.96

Rora

5.04

Il13ra1

0.69

Cebpb

1.72

Il1rl1

0.82

Stat1

1.58

Il18

0.84

Zbtb7b

0.83

Il2ra

0.35

Pou2f2

1.40

Ccl7

0.73

Maf

2.14

Il18rap

2.27

Stat6

0.97

Ccr4

1.34

Rorc

1.19

Il12p40

0.53

Runx1

1.29

Il1r1

3.90

Gata3

1.68

Il2

2.63

Zeb1

1.03

Ccl11

1.38

Nfatc2

2.01

Il12rb2

2.68

Foxp3

1.91

Il4ra

1.99

Nfatc2ip

1.53

Il9

6.13

Runx3

2.00

Il13

1.99

Hoxa3

1.22

  

Stat4

1.41

  
  1. cDNA samples were obtained from splenic cells of 24 weeks old female MRL/lpr mice 1 day after treatment. Values represent fold increase of LZ–SMS treatment (500 mg/kg/day of LZ–SMS formulation in 400 μL PBS for day 1–7 by oral administration followed by 50 mg/kg/day of soluble LZ–SMS in 400 μL PBS for day 8–14 by intraperitoneal route) versus the PBS treatment group
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Chinese Medicine

ISSN: 1749-8546

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