TY - JOUR AU - Lloyd-Jones, D. AU - Adams, R. J. AU - Brown, T. M. AU - Carnethon, M. AU - Dai, S. AU - Simone, G. AU - Ferguson, T. B. AU - Ford, E. AU - Furie, K. AU - Gillespie, C. AU - Go, A. AU - Greenlund, K. AU - Haase, N. AU - Hailpern, S. AU - Ho, P. M. AU - Howard, V. AU - Kissela, B. AU - Kittner, S. AU - Lackland, D. AU - Lisabeth, L. AU - Marelli, A. AU - McDermott, M. M. AU - Meigs, J. AU - Mozaffarian, D. AU - Mussolino, M. AU - Nichol, G. AU - Roger, V. L. AU - Rosamond, W. AU - Sacco, R. AU - Sorlie, P. AU - Roger, V. L. AU - Thom, T. AU - Wasserthiel-Smoller, S. AU - Wong, N. D. AU - Wylie-Rosett, J. PY - 2010 DA - 2010// TI - Heart disease and stroke statistics–2010 update: a report from the American Heart Association JO - Circulation VL - 121 UR - https://doi.org/10.1161/CIRCULATIONAHA.109.192667 DO - 10.1161/CIRCULATIONAHA.109.192667 ID - Lloyd-Jones2010 ER - TY - JOUR AU - Davis, S. AU - Lees, K. AU - Donnan, G. PY - 2006 DA - 2006// TI - Treating the acute stroke patient as an emergency: current practices and future opportunities JO - Int J Clin Pract VL - 60 UR - https://doi.org/10.1111/j.1368-5031.2006.00873.x DO - 10.1111/j.1368-5031.2006.00873.x ID - Davis2006 ER - TY - JOUR PY - 1995 DA - 1995// TI - Tissue plasminogen activator for acute ischemic stroke JO - N Engl J Med VL - 333 UR - https://doi.org/10.1056/NEJM199512143332401 DO - 10.1056/NEJM199512143332401 ID - ref3 ER - TY - JOUR AU - Armstead, W. M. AU - Ganguly, K. AU - Kiessling, J. W. AU - Riley, J. AU - Chen, X. H. AU - Smith, D. H. AU - Stein, S. C. AU - Higazi, A. A. AU - Cines, D. B. AU - Bdeir, K. AU - Zaitsev, S. AU - Muzykantov, V. R. PY - 2010 DA - 2010// TI - Signaling, delivery and age as emerging issues in the benefit/risk ratio outcome of tPA For treatment of CNS ischemic disorders JO - J Neurochem VL - 113 UR - https://doi.org/10.1111/j.1471-4159.2010.06613.x DO - 10.1111/j.1471-4159.2010.06613.x ID - Armstead2010 ER - TY - JOUR AU - Olmez, I. AU - Ozyurt, H. PY - 2012 DA - 2012// TI - Reactive oxygen species and ischemic cerebrovascular disease JO - Neurochem Int VL - 60 UR - https://doi.org/10.1016/j.neuint.2011.11.009 DO - 10.1016/j.neuint.2011.11.009 ID - Olmez2012 ER - TY - CHAP AU - Bretón, R. R. AU - Rodríguez, J. C. G. ED - Rodríguez, J. C. G. PY - 2012 DA - 2012// TI - Excitotoxicity and oxidative stress in acute ischemic stroke BT - Acute ischemic stroke PB - InTech CY - Shanghai ID - Bretón2012 ER - TY - JOUR AU - Petri, S. AU - Körner, S. AU - Kiaei, M. PY - 2012 DA - 2012// TI - Nrf2/ARE signaling pathway: key mediator in oxidative stress and potential therapeutic target in ALS JO - Neurol Res Int. VL - 2012 UR - https://doi.org/10.1155/2012/878030 DO - 10.1155/2012/878030 ID - Petri2012 ER - TY - JOUR AU - Rawal, A. K. AU - Muddeshwar, M. G. AU - Biswas, S. K. PY - 2004 DA - 2004// TI - Rubia cordifolia, Fagonia cretica Linn and Tinospora cordifolia exert neuroprotection by modulating the antioxidant system in rat hippocampal slices subjected to oxygen glucose deprivation JO - BMC Complement Altern Med. VL - 4 UR - https://doi.org/10.1186/1472-6882-4-11 DO - 10.1186/1472-6882-4-11 ID - Rawal2004 ER - TY - JOUR AU - Shih, A. Y. AU - Li, P. AU - Murphy, T. H. PY - 2005 DA - 2005// TI - A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo JO - J Neurosci VL - 25 UR - https://doi.org/10.1523/JNEUROSCI.4014-05.2005 DO - 10.1523/JNEUROSCI.4014-05.2005 ID - Shih2005 ER - TY - JOUR AU - Wu, Q. Q. AU - Wang, Y. AU - Senitko, M. AU - Meyer, C. AU - Wigley, W. C. AU - Ferguson, D. A. AU - Grossman, E. AU - Chen, J. AU - Zhou, X. J. AU - Hartono, J. AU - Winterberg, P. AU - Chen, B. AU - Agarwal, A. AU - Lu, C. Y. PY - 2011 DA - 2011// TI - Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1 JO - Am J Physiol Renal Physiol. VL - 300 UR - https://doi.org/10.1152/ajprenal.00353.2010 DO - 10.1152/ajprenal.00353.2010 ID - Wu2011 ER - TY - JOUR AU - Hatahet, F. AU - Ruddock, L. W. PY - 2009 DA - 2009// TI - Protein disulfide isomerase: a critical evaluation of its function in disulfide bond formation JO - Antioxid Redox Signal VL - 11 UR - https://doi.org/10.1089/ars.2009.2466 DO - 10.1089/ars.2009.2466 ID - Hatahet2009 ER - TY - JOUR AU - He, P. PY - 2008 DA - 2008// TI - Clinical efficacy of tian ma gou teng yin in the treatment of 100 cases of cerebral ischemia JO - Med J Chinese People’s Heal. VL - 20 ID - He2008 ER - TY - JOUR AU - Zhang, H. W. AU - Tong, J. AU - Zhou, G. AU - Jia, H. AU - Jiang, J. Y. PY - 2012 DA - 2012// TI - Tianma gouteng yin formula for treating primary hypertension JO - Cochrane Database Syst Rev VL - 6 ID - Zhang2012 ER - TY - JOUR AU - Zhang, C. Y. AU - Du, G. Y. AU - Wang, W. AU - Ye, Z. G. AU - Wang, D. Q. AU - Sun, X. F. AU - Zhao, D. Z. PY - 2004 DA - 2004// TI - Effects of Tianma Gouteng Fang on transmitter amino acids in the hippocampus extracellular liquids in freely moving rats subjected to brain ischemia JO - Chin J Chinese Mater Medica. VL - 29 ID - Zhang2004 ER - TY - JOUR AU - Chun, H. S. AU - Kim, J. M. AU - Choi, E. H. AU - Chang, N. PY - 2008 DA - 2008// TI - Neuroprotective effects of several Korean medicinal plants traditionally used for stroke remedy JO - J Med Food VL - 11 UR - https://doi.org/10.1089/jmf.2007.542 DO - 10.1089/jmf.2007.542 ID - Chun2008 ER - TY - JOUR AU - Su, S. Y. AU - Hsieh, C. L. PY - 2011 DA - 2011// TI - Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia JO - Chin Med. VL - 6 UR - https://doi.org/10.1186/1749-8546-6-26 DO - 10.1186/1749-8546-6-26 ID - Su2011 ER - TY - JOUR AU - Kim, H. J. AU - Hwang, I. K. AU - Won, M. H. PY - 2007 DA - 2007// TI - Vanillin, 4-hydroxybenzyl aldehyde and 4-hydroxybenzyl alcohol prevent hippocampal CA1 cell death following global ischemia JO - Brain Res VL - 1181 UR - https://doi.org/10.1016/j.brainres.2007.08.066 DO - 10.1016/j.brainres.2007.08.066 ID - Kim2007 ER - TY - JOUR AU - Lee, Y. S. AU - Ha, J. H. AU - Yong, C. S. AU - Lee, D. U. AU - Huh, K. AU - Kang, Y. S. AU - Lee, S. H. AU - Jung, M. W. AU - Kim, J. A. PY - 1999 DA - 1999// TI - Inhibitory effects of constituents of Gastrodia elata Bl. on glutamate-induced apoptosis in IMR-32 human neuroblastoma cells JO - Arch Pharm Res. VL - 22 UR - https://doi.org/10.1007/BF02979066 DO - 10.1007/BF02979066 ID - Lee1999 ER - TY - JOUR AU - Tsai, C. F. AU - Huang, C. L. AU - Lin, Y. L. AU - Lee, Y. C. AU - Yang, Y. C. AU - Huang, N. K. PY - 2011 DA - 2011// TI - The neuroprotective effects of an extract of Gastrodia elata JO - J Ethnopharmacol VL - 138 UR - https://doi.org/10.1016/j.jep.2011.08.064 DO - 10.1016/j.jep.2011.08.064 ID - Tsai2011 ER - TY - JOUR AU - Shimada, Y. AU - Goto, H. AU - Itoh, T. AU - Sakakibara, I. AU - Kubo, M. AU - Sasaki, H. AU - Terasawa, K. PY - 1999 DA - 1999// TI - Evaluation of the protective effects of alkaloids isolated from the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death in cultured cerebellar granule cells from rats JO - J Pharm Pharmacol VL - 51 UR - https://doi.org/10.1211/0022357991772853 DO - 10.1211/0022357991772853 ID - Shimada1999 ER - TY - JOUR AU - Yokoyama, K. AU - Shimada, Y. AU - Hori, E. AU - Sekiya, N. AU - Goto, H. AU - Sakakibara, I. AU - Nishijo, H. AU - Terasawa, K. PY - 2004 DA - 2004// TI - Protective effects of Choto-san and hooks and stems of Uncaria sinensis against delayed neuronal death after transient forebrain ischemia in gerbil JO - Phytomedicine VL - 11 UR - https://doi.org/10.1016/j.phymed.2003.04.001 DO - 10.1016/j.phymed.2003.04.001 ID - Yokoyama2004 ER - TY - BOOK AU - Hu, G. PY - 1958 DA - 1958// TI - Internal chinese medicine: new treatment methods PB - Sichuan People ‘s Publishing House CY - Chengdu ID - Hu1958 ER - TY - BOOK PY - 2010 DA - 2010// TI - Pharmacopedia of the People’s Republic of China PB - China Medical Science and Technology Press CY - Beijing ID - ref23 ER - TY - JOUR AU - Tabakman, R. AU - Jiang, H. AU - Shahar, I. AU - Arien-Zakay, H. AU - Levine, R. A. AU - Lazarovici, P. PY - 2005 DA - 2005// TI - Neuroprotection by NGF in the PC12 in vitro OGD model: involvement of mitogen-activated protein kinases and gene expression JO - Ann NY Acad Sci. VL - 1053 UR - https://doi.org/10.1196/annals.1344.008 DO - 10.1196/annals.1344.008 ID - Tabakman2005 ER - TY - JOUR AU - Williams, B. AU - Dwyer, D. S. PY - 2009 DA - 2009// TI - Structure-based discovery of low molecular weight compounds that stimulate neurite outgrowth and substitute for nerve growth factor JO - J Neurochem VL - 110 UR - https://doi.org/10.1111/j.1471-4159.2009.06291.x DO - 10.1111/j.1471-4159.2009.06291.x ID - Williams2009 ER - TY - JOUR AU - Wang, H. AU - Joseph, J. A. PY - 1999 DA - 1999// TI - Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader JO - Free Radic Biol Med VL - 27 UR - https://doi.org/10.1016/S0891-5849(99)00107-0 DO - 10.1016/S0891-5849(99)00107-0 ID - Wang1999 ER - TY - JOUR AU - Eruslanov, E. AU - Kusmartsev, S. PY - 2010 DA - 2010// TI - Identification of ROS using oxidized DCFDA and flow-cytometry JO - Methods Mol Biol VL - 594 UR - https://doi.org/10.1007/978-1-60761-411-1_4 DO - 10.1007/978-1-60761-411-1_4 ID - Eruslanov2010 ER - TY - JOUR AU - Jin, Z. J. PY - 2004 DA - 2004// TI - About the evaluation of drug combination JO - Acta Pharm Sin. VL - 25 ID - Jin2004 ER - TY - JOUR AU - Bederson, J. B. AU - Pitts, L. H. AU - Germano, S. M. AU - Nishimura, M. C. AU - Davis, R. L. AU - Bartkowski, H. M. PY - 1986 DA - 1986// TI - Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats JO - Stroke VL - 17 UR - https://doi.org/10.1161/01.STR.17.6.1304 DO - 10.1161/01.STR.17.6.1304 ID - Bederson1986 ER - TY - JOUR AU - Zhan, C. AU - Yang, J. PY - 2006 DA - 2006// TI - Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats JO - Pharmacol Res VL - 53 UR - https://doi.org/10.1016/j.phrs.2005.12.008 DO - 10.1016/j.phrs.2005.12.008 ID - Zhan2006 ER - TY - JOUR AU - Bederson, J. B. AU - Pitts, L. H. AU - Tsuji, M. AU - Nishimura, M. C. AU - Davis, R. L. AU - Bartkowski, H. PY - 1986 DA - 1986// TI - Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination JO - Stroke VL - 17 UR - https://doi.org/10.1161/01.STR.17.3.472 DO - 10.1161/01.STR.17.3.472 ID - Bederson1986 ER - TY - JOUR AU - Feeney, D. M. AU - Gonzalez, A. AU - Law, W. A. PY - 1982 DA - 1982// TI - Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury JO - Science VL - 217 UR - https://doi.org/10.1126/science.7100929 DO - 10.1126/science.7100929 ID - Feeney1982 ER - TY - JOUR AU - Goldstein, L. B. AU - Davis, J. N. PY - 1990 DA - 1990// TI - Beam-walking in rats: studies towards developing an animal model of functional recovery after brain injury JO - J Neurosci Methods VL - 31 UR - https://doi.org/10.1016/0165-0270(90)90154-8 DO - 10.1016/0165-0270(90)90154-8 ID - Goldstein1990 ER - TY - JOUR AU - Urakawa, S. AU - Hida, H. AU - Masuda, T. AU - Misumi, S. AU - Kim, T. S. AU - Nishino, H. PY - 2007 DA - 2007// TI - Environmental enrichment brings a beneficial effect on beam walking and enhances the migration of doublecortin-positive cells following striatal lesions in rats JO - Neuroscience VL - 144 UR - https://doi.org/10.1016/j.neuroscience.2006.10.038 DO - 10.1016/j.neuroscience.2006.10.038 ID - Urakawa2007 ER - TY - JOUR AU - Alexandrova, M. L. AU - Bochev, P. G. PY - 2005 DA - 2005// TI - Oxidative stress during the chronic phase after stroke JO - Free Radic Biol Med VL - 39 UR - https://doi.org/10.1016/j.freeradbiomed.2005.04.017 DO - 10.1016/j.freeradbiomed.2005.04.017 ID - Alexandrova2005 ER - TY - JOUR AU - Domínguez, C. AU - Delgado, P. AU - Vilches, A. AU - Martín-Gallán, P. AU - Ribó, M. AU - Santamarina, E. AU - Molina, C. AU - Corbeto, N. AU - Rodríguez-Sureda, V. AU - Rosell, A. AU - Alvarez-Sabín, J. AU - Montaner, J. PY - 2010 DA - 2010// TI - Oxidative stress after thrombolysis-induced reperfusion in human stroke JO - Stroke VL - 41 UR - https://doi.org/10.1161/STROKEAHA.109.571935 DO - 10.1161/STROKEAHA.109.571935 ID - Domínguez2010 ER - TY - JOUR AU - Glantz, L. AU - Avramovich, A. AU - Trembovler, V. AU - Gurvitz, V. AU - Kohen, R. AU - Eidelman, L. A. AU - Shohami, E. PY - 2005 DA - 2005// TI - Ischemic preconditioning increases antioxidants in the brain and peripheral organs after cerebral ischemia JO - Exp Neurol VL - 192 UR - https://doi.org/10.1016/j.expneurol.2004.11.012 DO - 10.1016/j.expneurol.2004.11.012 ID - Glantz2005 ER - TY - JOUR AU - Baker, K. AU - Marcus, C. B. AU - Huffman, K. AU - Kruk, H. AU - Malfroy, B. AU - Doctrow, S. R. PY - 1998 DA - 1998// TI - Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury JO - J Pharmacol Exp Ther VL - 284 ID - Baker1998 ER - TY - JOUR AU - Nguyen, T. AU - Nioi, P. AU - Pickett, C. B. PY - 2009 DA - 2009// TI - The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress JO - J Biol Chem VL - 284 UR - https://doi.org/10.1074/jbc.R900010200 DO - 10.1074/jbc.R900010200 ID - Nguyen2009 ER - TY - JOUR AU - Venugopal, R. AU - Jaiswal, A. K. PY - 1996 DA - 1996// TI - Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene JO - Proc Natl Acad Sci USA VL - 93 UR - https://doi.org/10.1073/pnas.93.25.14960 DO - 10.1073/pnas.93.25.14960 ID - Venugopal1996 ER - TY - JOUR AU - Leonard, M. O. AU - Kieran, N. E. AU - Howell, K. AU - Burne, M. J. AU - Varadarajan, R. AU - Dhakshinamoorthy, S. AU - Porter, A. G. AU - O’Farrelly, C. AU - Rabb, H. AU - Taylor, C. T. PY - 2006 DA - 2006// TI - Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury JO - FASEB J. VL - 20 UR - https://doi.org/10.1096/fj.06-5097fje DO - 10.1096/fj.06-5097fje ID - Leonard2006 ER - TY - JOUR AU - Tanaka, S. AU - Uehara, T. AU - Nomura, Y. PY - 2000 DA - 2000// TI - Up-regulation of protein-disulfide isomerase in response to hypoxia/brain ischemia and its protective effect against apoptotic cell death JO - J Biol Chem VL - 275 UR - https://doi.org/10.1074/jbc.275.14.10388 DO - 10.1074/jbc.275.14.10388 ID - Tanaka2000 ER - TY - JOUR AU - Miyata, T. AU - Takizawa, S. AU - Ypersele de Strihou, C. PY - 2011 DA - 2011// TI - Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets JO - Am J Physiol Cell Physiol VL - 300 UR - https://doi.org/10.1152/ajpcell.00430.2010 DO - 10.1152/ajpcell.00430.2010 ID - Miyata2011 ER - TY - JOUR AU - Işlekel, S. AU - Işlekel, H. AU - Güner, G. AU - Ozdamar, N. PY - 1999 DA - 1999// TI - Alterations in superoxide dismutase, glutathione peroxidase and catalase activities in experimental cerebral ischemia-reperfusion JO - Res Exp Med VL - 199 UR - https://doi.org/10.1007/s004330050121 DO - 10.1007/s004330050121 ID - Işlekel1999 ER - TY - JOUR AU - Lee, J. C. AU - Won, M. H. PY - 2014 DA - 2014// TI - Neuroprotection of antioxidant enzymes against transient global cerebral ischemia in gerbils JO - Anat Cell Biol. VL - 47 UR - https://doi.org/10.5115/acb.2014.47.3.149 DO - 10.5115/acb.2014.47.3.149 ID - Lee2014 ER - TY - JOUR AU - Sanchez-Covarrubias, L. AU - Slosky, L. M. AU - Thompson, B. J. AU - Davis, T. P. AU - Ronaldson, P. T. PY - 2014 DA - 2014// TI - Transporters at CNS barrier sites: obstacles or opportunities for drug delivery? JO - Curr Pharm Des VL - 20 UR - https://doi.org/10.2174/13816128113199990463 DO - 10.2174/13816128113199990463 ID - Sanchez-Covarrubias2014 ER - TY - JOUR AU - Lin, L. C. AU - Chen, Y. F. AU - Tsai, T. R. AU - Tsai, T. H. PY - 2007 DA - 2007// TI - Analysis of brain distribution and biliary excretion of a nutrient supplement, gastrodin, in rat JO - Anal Chim Acta VL - 590 UR - https://doi.org/10.1016/j.aca.2007.03.035 DO - 10.1016/j.aca.2007.03.035 ID - Lin2007 ER - TY - JOUR AU - Lin, L. C. AU - Chen, Y. F. AU - Lee, W. C. AU - Wu, Y. T. AU - Tsai, T. H. PY - 2008 DA - 2008// TI - Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC-MS/MS JO - J Pharm Biomed Anal VL - 8 UR - https://doi.org/10.1016/j.jpba.2008.07.013 DO - 10.1016/j.jpba.2008.07.013 ID - Lin2008 ER - TY - JOUR AU - Lee, C. J. AU - Hsueh, T. Y. AU - Lin, L. C. AU - Tsai, T. H. PY - 2014 DA - 2014// TI - Determination of protein-unbound rhynchiphylline brain distribution by microdialysis and ultra-performance liquid chromatography with tandem mass spectrometry JO - Biomed Chromatogr VL - 28 UR - https://doi.org/10.1002/bmc.3206 DO - 10.1002/bmc.3206 ID - Lee2014 ER - TY - JOUR AU - Østergaard, L. AU - Jespersen, S. N. AU - Mouridsen, K. AU - Mikkelsen, I. K. AU - Jonsdottír, K. Ý. AU - Tietze, A. AU - Blicher, J. U. AU - Aamand, R. AU - Hjort, N. AU - Iversen, N. K. AU - Cai, C. AU - Hougaard, K. D. AU - Simonsen, C. Z. AU - Weitzel-Mudersbach, P. AU - Modrau, B. AU - Nagenthiraja, K. AU - Ribe, R. L. AU - Hansen, M. B. AU - Bekke, S. L. AU - Dahlman, M. G. AU - Puig, J. AU - Pedraza, S. AU - Serena, J. AU - Cho, T. H. AU - Siemonsen, S. AU - Thomalla, G. AU - Fiehler, J. AU - Nighoghossian, N. AU - Andersen, G. PY - 2013 DA - 2013// TI - The role of the cerebral capillaries in acute ischemic stroke: the extended penumbra model JO - J Cereb Blood Flow Metab VL - 33 UR - https://doi.org/10.1038/jcbfm.2013.18 DO - 10.1038/jcbfm.2013.18 ID - Østergaard2013 ER - TY - JOUR AU - Jaiswal, Y. AU - Liang, Z. AU - Yong, P. AU - Chen, H. AU - Zhao, Z. PY - 2013 DA - 2013// TI - A comparative study on the traditional Indian Shodhana and Chinese processing methods for aconite roots by characterization and determination of the major components JO - Chem Cent J VL - 7 UR - https://doi.org/10.1186/1752-153X-7-169 DO - 10.1186/1752-153X-7-169 ID - Jaiswal2013 ER - TY - JOUR AU - Liu, Y. AU - Yang, J. AU - Cai, Z. PY - 2006 DA - 2006// TI - Chemical investigation on Sijunzi decoction and its two major herbs Panax ginseng and Glycyrrhiza uralensis by LC/MS/MS JO - J Pharm Biomed Anal VL - 41 UR - https://doi.org/10.1016/j.jpba.2006.02.033 DO - 10.1016/j.jpba.2006.02.033 ID - Liu2006 ER -