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Table 5 Summary of combination of CHM and Western medicine and the reported adverse effects

From: Chinese herbal medicine for constipation: zheng-based associations among herbs, formulae, proprietary medicines, and herb–drug interactions

 

Combined used Western medicine

Frequency of reported in all the trials (n > 5)

Adverse effect (N = , percentage, %)

Single herb

 Da Huang

Sodium bicarbonate tablets

23

Symptoms of the gastrointestinal tract (N = 4, 17.3 %)

Insomnia (N = 1, 4.3 %)

Skin rash (N = 1, 4.3 %)

Headache (N = 1, 4.3 %)

 Fan Xie Ye

Lactulose oral solution

8

Symptoms of the gastrointestinal tract (N = 2, 25 %)

Dizzy and anorexia (N = 1, 12.5 %)

CHM Proprietary

 Ma-Ren-Ruan-Jiao-Nang

Lactulose oral solution

6

Symptoms of the gastrointestinal tract (N = 2, 33.3 %)

Headache (N = 1, 16.7 %)

 Liu-Wei-An-Xiao-Jiao-Nang

Mosapride citrate tablets

6

Symptoms of the gastrointestinal tract (N = 3, 50 %)