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Fig. 2 | Chinese Medicine

Fig. 2

From: Chi-Ju-Di-Huang-Wan protects rats against retinal ischemia by downregulating matrix metalloproteinase-9 and inhibiting p38 mitogen-activated protein kinase

Fig. 2

The thicknesses of various retinal layers. This figure shows sections of retina from approximately the same eccentricity. (a sham 1 day) and (f sham 7 days) show sections of Group 1 1 day and 7 days following the sham procedure, respectively. Pictures b and g respectively show retinas that received ischemia plus reperfusion (I/R) for 1 day (I/R 1 day + Vehicle) or 7 days and pretreatment of vehicle (I/R 7 days + vehicle; Group 2). Compared with the Group 1 (a, f), the thickness of the inner retina [INL inner nuclear layer, IPL inner plexiform layer and ganglion cell layer] in the ischemic retina pretreated with vehicle (Group 2; b, g) was reduced considerably. This reduction in the thickness of the inner retinal layers was attenuated in animals given I/R for 1 or 7 days and pretreated with 2.8 g/kg/day [Group 3; on I/R day 1, (c) on I/R day 7, (h)] and 4.2 g/kg/day of CJDHW [Group 4; on I/R day 1, (d) on I/R day 7, (i)]. Scale bar = 50 μm. Morphometric analysis of the thicknesses of various retinal layers from sections of similar eccentricity (e, j). Compared with the Group 1 (sham 1 day; sham 7 days), the thicknesses of the whole retinal layer, INL and IPL were significantly reduced in the vehicle-treated ischemic retinas (Group 2). Moreover, these reductions were attenuated in a dose-dependent manner when the ischemic retinas were pretreated with 2.8 (Group 3) and 4.2 g/kg/day of CJDHW (Group 4). Results are the mean ± SD of the number of experiments (n = 4–6). *or **significantly different (P < 0.05 or P < 0.01) from the Group 1. or ††significantly different (P < 0.05 or P < 0.01) from the Group 2 on I/R day 1 or 7. Total whole retina, CJDHW Chi-Ju-Di-Huang-Wan

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