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Table 2 Hematoxylin and eosin staining

From: Chi-Ju-Di-Huang-Wan protects rats against retinal ischemia by downregulating matrix metalloproteinase-9 and inhibiting p38 mitogen-activated protein kinase

Group 1 2 3 4
Retinal thickness on day 1
 Whole 174.12 ± 3.64 165.43 ± 4.44** 168.45 ± 12.89 172.00 ± 1.57
 INL 41.68 ± 2.69 37.13 ± 5.04* 37.52 ± 2.09 39.74 ± 3.13
 IPL 41.93 ± 1.58 36.81 ± 2.21** 37.16 ± 4.55 40.39 ± 0.86
Retinal thickness on day 7
 Whole 180.25 ± 4.35 141.02 ± 9.47** 156.18 ± 7.92 171.78 ± 10.38††
 INL 38.10 ± 1.39 24.74 ± 3.60** 29.23 ± 5.43 34.45 ± 4.02
 IPL 38.38 ± 1.43 20.34 ± 1.79** 26.20 ± 3.60 33.53 ± 1.85
  1. In comparison of the control retina, 1 or 7 days following sham procedure (Group 1; Sham 1 day, n = 6; Sham 7 days, n = 6), after retinal ischemia plus 1 or 7 days of reperfusion and pretreatment with vehicle (Group 2; I/R 1 day + vehicle, n = 4; I/R 7 days + vehicle, n = 5), there was a significant decrease (* P < 0.05; ** P < 0.01) in the thickness of the whole retina, the INL and the IPL. In contrast, this significant decrease was dose-dependently (with a less effect at 2.8 g/kg/day, I/R + CJDHW2.8, Group 3, n = 4) and significantly ( P < 0.05; †† P < 0.01; Group 3; I/R + CJDHW4.2, Group 4, n = 4) inhibited by pretreatment with CJDHW. The results are the mean ± SD (μm)
  2. CJDHW4.2 Chi-Ju-Di-Huang-Wan at 4.2 g/kg/day, INL inner nuclear layer, IPL inner plexiform layer