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Table 3 Choline acetyltransferase (ChAT) immunolabelling

From: Chi-Ju-Di-Huang-Wan protects rats against retinal ischemia by downregulating matrix metalloproteinase-9 and inhibiting p38 mitogen-activated protein kinase

Group 1 2 3 4
Cholinergic amacrines (number/field) on day 1 34.33 ± 6.59 12.67 ± 2.80* 28.33 ± 2.16 31.67 ± 3.88
Cholinergic amacrines (number/field) on day 7 36.83 ± 6.68 13.17 ± 4.07* 23.50 ± 3.45 28.50 ± 4.59
  1. In comparison of the control retina, 1 or 7 days following sham procedure (Sham; Group 1), after retinal ischemia plus 1 or 7 days of reperfusion and pretreatment with vehicle (I/R + vehicle; Group 2), the number of CHAT-immunolabeling amacrine cells per field was significantly decreased (* P < 0.05) in the inner nuclear layer and the ganglion cell layer. In contrast, this significant decrease was dose-dependently (with a less effect at 2.8 g/kg/day, I/R + CJDHW2.8, Group 3) and significantly ( P < 0.05; Group 3; I/R + CJDHW4.2, Group 4) inhibited by pretreatment with CJDHW. The results are the mean ± SD (n = 6)