From: Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan)
Component | Animal model | Anti-cancer activitya | Reference |
---|---|---|---|
Gypenosides | Nude mice: xenografted with human oral cancer SAS cells | 65.76Â % (tumor size, 20Â mg/kg for 28Â days) | [89] |
Gypenosides | BALB/c mice: injected with human leukemia WEHI-3 cells | 150Â % (survival rate, 2Â mg/kg for 2Â weeks) 175Â % (survival rate, 4Â mg/kg for 2Â weeks) | [90] |
Gypenosides | Nude mice: xenografted with human leukemia HL-60 cells | 44Â % (tumor size, 20Â mg/kg for 28Â days) | [91] |
Gypenosides | BALB/c mice: xenografted with murine S180 sarcoma cells | 39.57Â % (tumor size, 30Â mg/kg for 4Â days) | [92] |
Gypenosides | BALB/c mice: xenografted with murine colorectal cancer CT-26 cells | 75 % (tumor size, 25 mg/kg for 19 days) 55 % (tumor size, 50 mg/kg for 19 days) 26 % (tumor size, 50 mg/kg + 5 mg/kg 5-Fu for 19 days) | [93] |
Gypenosides | Apc Min/+ mice: intestinal neoplasia model | 66.06Â % (polyps number, 500Â mg/kg for 4Â weeks) 59.92Â % (polyps number, 750Â mg/kg for 4Â weeks) | [94] |
Gypenosides | Apc Min/+ mice: intestinal neoplasia model | 59.32Â % (polyps number, 500Â mg/kg for 8Â weeks) | [95] |
Polysaccharide | BALB/c mice: xenografted with murine S180 sarcoma cells | 62.77Â % (tumor size, 100Â mg/kg for 14Â days) 59.24Â % (tumor size, 200Â mg/kg for 14Â days) | [97] |
Polysaccharide | ICR mice: xenografted with mouse hepatoma H22 cells | 62.89Â % (tumor size, 50Â mg/kg for 10Â days) 49.22Â % (tumor size, 200Â mg/kg for 10Â days) | [20] |