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Fig. 11 | Chinese Medicine

Fig. 11

From: Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability

Fig. 11

Schematic diagram of hypothesized mechanism of trans-FA effect of lung cancer cells. Trans-FA induced ROS leading to degradation of phosphorylated β-catenin. Trans-FA induced regulation of pro-survival proteins survivin and anti-survival protein Bax caused the anti-proliferation of lung cancer H1299 cells. Trans-FA also reduced the activity of both MMP-2 and MMP-9, causing the down-regulation of migration of H1299 cells

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Chinese Medicine

ISSN: 1749-8546

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