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Table 2 Combination index (CI) and dose reduction index (DRI) values at 48 h for bromelain and cisplatin combinations. CI < 1 indicates synergistic effect, CI = 1 indicates additive effects and CI > 1 indicates antagonistic effect

From: Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro

Combination no. Combination dosage (µM) CI value DRI (bromelain) DRI (cisplatin)
Bromelain dosage (IC value) Cisplatin dosage (IC value)
Combination 1 2.0 µM (IC40) 1.5 µM (IC10) 0.65 1.74 12.71
Combination 2 0.9 µM (IC30) 4.0 µM (IC20) 1.36 1.27 1.73
Combination 3 0.5 µM (IC20) 5.9 µM (IC30) 0.78 3.87 1.89
Combination 4 0.24 µM (IC10) 9.5 µM (IC40) 0.75 10.59 1.50