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Table 2 Combination index (CI) and dose reduction index (DRI) values at 48 h for bromelain and cisplatin combinations. CI < 1 indicates synergistic effect, CI = 1 indicates additive effects and CI > 1 indicates antagonistic effect

From: Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro

Combination no.

Combination dosage (µM)

CI value

DRI (bromelain)

DRI (cisplatin)

Bromelain dosage (IC value)

Cisplatin dosage (IC value)

Combination 1

2.0 µM (IC40)

1.5 µM (IC10)

0.65

1.74

12.71

Combination 2

0.9 µM (IC30)

4.0 µM (IC20)

1.36

1.27

1.73

Combination 3

0.5 µM (IC20)

5.9 µM (IC30)

0.78

3.87

1.89

Combination 4

0.24 µM (IC10)

9.5 µM (IC40)

0.75

10.59

1.50

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