Mechanisms for the anti-obesity actions of bofutsushosan in high-fat diet-fed obese mice

Chinese Medicine

Table 2 Effects of BTS on mRNA expression of leptin, adiponectin, UCP1, and UCP2 in interscapular brown adipose tissue and epididymal white adipose tissues after 5 days’ administration

	−BTS	+BTS	P value
Interscapular brown adipose tissue
Leptin	0.0264 ± 0.0080	0.1182 ± 0.0612	0.0004
Adiponectin	0.7679 ± 0.2436	2.5412 ± 2.1369	0.0250
UCP1	2.2519 ± 0.9376	3.3746 ± 0.6704	0.0100
UCP2	0.0717 ± 0.0210	0.0833 ± 0.0430	0.4781
Epididymal white adipose tissue
Leptin	0.0512 ± 0.0243	0.0390 ± 0.0203	0.3756
Adiponectin	0.6115 ± 0.5319	0.9395 ± 0.4682	0.1839
UCP1	0.0015 ± 0.0008	0.0020 ± 0.0014	0.5207
UCP2	0.1560 ± 0.0252	0.1777 ± 0.0930	0.5347

Relative quantification of mRNA expression by real-time PCR was calculated relative to β-actin mRNA. Values are expressed as mean ± SD (n = 4–9). P values were calculated by Student’s t test. P < 0.05, BTS group is considered significantly different from control group without BTS

ISSN: 1749-8546