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Fig. 7 | Chinese Medicine

Fig. 7

From: Jiangtang decoction ameliorate diabetic nephropathy through the regulation of PI3K/Akt-mediated NF-κB pathways in KK-Ay mice

Fig. 7

JTD activates the PI3K/Akt signaling pathway and inhibits NF-κB signaling pathways. a Representative Western blots of phosphorylated PI3K (Tyr 458), PI3K p85, phosphorylated Akt (Ser 473), Akt (pan), and GAPDH proteins isolated from the mouse kidneys of different groups. Protein bands shown are representative of >3 independent experiments with similar results. b JTD up-regulates the phosphorylation of PI3K; c JTD up-regulates the amount of phosphorylated Akt (Ser473); d JTD up-regulates PI3K p85mRNA expression; e JTD up-regulates the mRNA expression of Akt (pan); f representative Western blots of IκBα as well as phosphorylated NF-κB p65, NF-κB p65, and GAPDH proteins isolated from the mouse kidneys of different groups. The protein bands are representative of >3 independent experiments with similar results. g JTD down-regulates the protein expression of IκBα in the kidney; h JTD downregulates the phosphorylation of NF-κB p65; i JTD down-regulates the mRNA expression of IKKβ. Data are expressed as the mean ± S.D.; N = 10; *P < 0.05; **P < 0.01; and ***P < 0.001 compared to the model group

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