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Table 3 Risk of bias assessment of the included studies using the Cochrane risk of bias tool

From: Efficacy of Chinese herbal medicine for stroke modifiable risk factors: a systematic review

Author, Country, Publication year Stroke risk factor Random sequence generation Allocation concealment Blinding of participants and personnel Blinding of outcome assessment Incomplete outcome data Selective reporting Other bias
Lin et al. [18], China, 2004 (Primary) Hypertension Unclear Unclear High risk Unclear Low risk Unclear Unclear
Li [19], China, 2005 (Primary) Hypertension Unclear Unclear High risk Unclear Unclear Unclear Unclear
Ye et al. [20], China, 2009 (Primary) Hypertension Unclear Unclear Low risk Low risk Unclear Low risk Unclear
Zhao et al. [21], China, 2010 (Primary) Hypertension Unclear Unclear Low risk Unclear Unclear Unclear Unclear
Zhong et al. [22], China, 2011 (Primary) Hypertension Low risk High risk High risk Unclear Low risk Low risk Unclear
Yang et al. [23], Taiwan, 2012 (Uncontrolled primary) Hypertension Low risk Unclear High risk Low risk Unclear Low risk High risk
Tong et al. [24], China, 2013 Hypertension Low risk High risk High risk Low risk Unclear Low risk Unclear
Wu et al. [25], China, 2014 (Primary) Hypertension Low risk Low risk Unclear Low risk Low risk Low risk Unclear
Li et al. [26], China, 2010 (Isolated systolic) Hypertension Low risk Unclear Low risk Unclear High risk Unclear Unclear
Chen et al. [27], China, 2012 (Polarized) Hypertension Low risk Unclear High risk Unclear Unclear Unclear High risk
Gong et al. [28], China, 2010 Hypertension with cardiac damage Unclear Unclear High risk Unclear Low risk Unclear Unclear
Xu et al. [29], China, 2013 Hypertension, hypertension with diabetes, hypertension with coronary heart disease Unclear Unclear High risk Unclear Unclear Low risk High risk
Chao et al. [30], China, 2009 Type 2 diabetes Low risk Low risk Low risk Low risk Low risk Low risk Unclear
Ji et al. [31], China, 2013 Type 2 diabetes Low risk Low risk High risk Low risk Low risk Low risk Unclear
Tong et al. [32], China, 2013 Type 2 diabetes Low risk Unclear Low risk Low risk High risk Unclear Unclear
Tu et al. [33], China, 2013 Type 2 diabetes Low risk Low risk High risk Unclear Low risk Low risk Unclear
Wu & Fan [34], China, 2014 Type 2 diabetes Unclear Unclear High risk Unclear Unclear Unclear Unclear
Cai et al. [35], China, 2015 Type 2 diabetes Low risk Unclear Low risk Unclear Low risk Low risk Unclear
Lian et al. [36], China, 2015 Type 2 diabetes Low risk Low risk Low risk Low risk Low risk Low risk Unclear
Zhang et al. [37], China, 2015 Type 2 diabetes Low risk Low risk High risk Unclear Unclear Low risk Unclear
Hu et al. [38], China, 2016 Type 2 diabetes Low risk High risk Low risk Low risk High risk Low risk Unclear
Li et al. [39], China, 2016 Type 2 diabetes Low risk Low risk Low risk Low risk Low risk Low risk Unclear
Wang et al. [40], China, 1997 Hyperlipidemia Low risk Unclear High risk Low risk Low risk Low risk Unclear
Yang et al. [41], China, 2006 Hyperlipemia Unclear Unclear Unclear Unclear Unclear Unclear High risk
Ai et al. [42], China, 2009 Hyperlipemia High risk High risk High risk High risk Unclear Low risk High risk
Xu et al. [43], China, 2009 Hyperlipemia Unclear Unclear High risk Unclear Unclear Unclear Unclear
Hu et al. [44], Hong Kong, 2014 Hyperlipemia Low risk Low risk Low risk Unclear Low risk Low risk High risk
Moriarty et al. [45], USA & China, 2014 Hyperlipemia Low risk Low risk Low risk Unclear Low risk Low risk Unclear
Heber et al. [46], USA, 1999 Hyperlipidemia Unclear Unclear Low risk Unclear Low risk Low risk High risk
Lin et al. [47], Taiwan, 2005 Hyperlipidemia High risk Unclear Low risk Low risk Low risk Low risk High risk
Wei et al. [48], China, 2008 Impaired glucose tolerance High risk Unclear High risk Unclear Low risk Unclear Unclear
Gao et al. [49], China, 2013 Impaired glucose tolerance Low risk Unclear High risk Unclear Low risk Low risk Unclear
Fang et al. [50], China, 2014 Impaired glucose tolerance Unclear Unclear High risk Unclear Low risk Low risk Unclear
Lian et al. [51], China, 2014 Impaired glucose tolerance Low risk Low risk Low risk Low risk Low risk Low risk Unclear
Huang et al. [52], China, 2016 Impaired glucose tolerance Low risk Low risk High risk Unclear Low risk Low risk Unclear
Shi et al. [53], China, 2016 Impaired glucose tolerance Low risk Unclear High risk Unclear High risk Low risk Unclear
Grant et al. [54], Australia, 2013 Impaired glucose tolerance Low risk Low risk Low risk Low risk Low risk Unclear High risk
Pan et al. [55], China, 2005 Obesity Low risk Unclear Low risk Unclear Low risk Unclear High risk
Zhou et al. [56], China, 2014 Obesity Low risk Unclear Low risk Unclear Unclear Low risk Unclear
Lenon et al. [57], Australia, 2012 Obesity Unclear Low risk Low risk Unclear Low risk Low risk Unclear
Hioki et al. [58], Japan, 2004 Obesity and impaired glucose tolerance Low risk High risk Low risk Unclear Unclear Low risk High risk
Gao & Hu [59], China, 2006 Type 2 diabetes and hyperlipidemia Unclear Unclear High risk Unclear Low risk Low risk Unclear
Poppel et al. [60], Netherlands, 2015 Hyperlipidemia and hypertension High risk Unclear Low risk Unclear Low risk Low risk High risk
Chu et al. [61], China, 2011 Metabolic syndrome High risk Unclear Low risk Unclear Low risk Low risk Unclear
Chen et al. [62], China, 2013 Hypertension and metabolic syndrome Low risk Unclear Low risk Unclear High risk Low risk Unclear
Azushima et al. [63], Japan, 2015 Hypertension and obesity Low risk Unclear High risk High risk Low risk Low risk High risk