Effect of methanol extract of Salviae miltiorrhizae Radix in high-fat diet-induced hyperlipidemic mice

Chinese Medicine

Table 3 Functional enrichments in protein network

Pathway ID	Pathway description	Count in gene set	False discovery rate
Biological process (GO)
GO:0006270	DNA replication initiation	4	0.00262
GO:0006268	DNA unwinding involved in DNA replication	3	0.0227
Molecular function (GO)
GO:0003678	DNA helicase activity	4	0.00299
GO:0004386	Helicase activity	6	0.00299
GO:0032559	Adenyl ribonucleotide binding	16	0.00299
GO:0036094	Small molecule binding	21	0.00299
GO:0000166	Nucleotide binding	19	0.00685
GO:0004691	cAMP-dependent protein kinase activity	2	0.00951
GO:0004748	Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	2	0.00951
GO:0097367	Carbohydrate derivative binding	18	0.00951
GO:0005524	ATP binding	14	0.0139
GO:0043168	Anion binding	19	0.0149
GO:0051018	Protein kinase A binding	3	0.023
Cellular component (GO)
GO:0042555	MCM complex	6	2.29e−10
GO:0005952	cAMP-dependent protein kinase complex	3	0.00123
GO:0097362	MCM8-MCM9 complex	2	0.00495
GO:0070033	Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex	2	0.0111
GO:0070032	Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	2	0.0178

GO terms and pathways associated with differentially expressed genes of liver tissues in hyperlipidemic mice. False discovery rate corrections were calculated using the Benjamini–Hochberg procedure

ISSN: 1749-8546