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Fig. 7 | Chinese Medicine

Fig. 7

From: Active fraction (HS7) from Taiwanofungus camphoratus inhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells

Fig. 7

Effects of synthetic inhibitors and HS7 on the AKT ERK and STAT3 signaling pathways in CL1-0 lung cancer cells after 72 h of treatment. a The cell viabilities of CL1-0 cells were measured after treatment with LY294002 (PI3K-AKT inhibitor), U0126 (MEK-ERK inhibitor) or AG490 (JAK-STAT3 inhibitor) at indicated doses for 72 h. Cell viability data (mean ± SE) are expressed as a percentage compared to the control and analyzed as described in “Statistical analysis”. ***p < 0.001 compared to the control group. b The effects of LY294002, U0126, AG490 and HS7 on the protein levels of phosphorylated AKT (p-AKT), phosphorylated ERK (p-ERK), ERK, phosphorylated STAT3 (p-STAT3) and HIF-1α in CL1-0 cells. Cell lysates were analyzed by Western blot, using GAPDH as loading control

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Chinese Medicine

ISSN: 1749-8546

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