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Table 5 Absorption parameters of triptonide of various formulae in perfusate solution within duodenum, jejunum, ileum and colon (\( {\bar{\text{x}}} \pm {\text{s}} \), n = 6)

From: Different modulation of Panax notoginseng on the absorption profiling of triptolide and tripterine from Tripterygium wilfordii in rat intestine

Parameters

Con. (μg/mL)

Duodenum

Jejunum

Ileum

Colon

Peff × 10−3

Triptonide

11.6 ± 2.95

8.77 ± 1.47

9.34 ± 2.92

8.40 ± 1.94

TW

13.3 ± 3.43

8.98 ± 1.26

11.3 ± 3.3

10.4 ± 2.04

TW-PN

7.86 ± 1.36**

6.12 ± 1.38**

7.05 ± 1.29*

6.6 ± 1.57**

TW-CS

12.8 ± 1.28

7.68 ± 1.64

9.93 ± 2.73

8.44 ± 1.31

QLTB

5.55 ± 0.55**

5.48 ± 1.07**

4.75 ± 1.18**

5.22 ± 1.13**

10 cm%ABS

Triptonide

46.1 ± 2.89

44.9 ± 3.67

44.5 ± 3.31

45.6 ± 3.76

TW

51.2 ± 8.5

46.8 ± 5.76

47.7 ± 7.12

49.7 ± 4.5

TW-PN

40.4 ± 4.7*

33.6 ± 3.04**

37.0 ± 6.96*

35.9 ± 5.8**

TW-CS

46.8 ± 5.3

41.3 ± 4.09

44.4 ± 4.18

45.6 ± 3.1

QLTB

34.0 ± 5.7**

31.9 ± 3.27**

31.1 ± 7.18**

33.8 ± 3.4**

Ka × 10−2

Triptonide

5.64 ± 1.22

2.60 ± 0.23

1.15 ± 0.47

1.33 ± 0.66

TW

6.03 ± 1.03

2.81 ± 0.18

1.32 ± 0.55

1.53 ± 0.46

TW-PN

4.51 ± 0.83*

1.86 ± 0.14**

1.47 ± 0.68

0.99 ± 0.33*

TW-CS

2.9 ± 1.68**

1.46 ± 0.28**

1.23 ± 0.78

1.37 ± 0.49

QLTB

3.13 ± 1.11**

1.42 ± 0.08**

1.39 ± 0.36

0.70 ± 0.13**

  1. * p < 0.05, ** p < 0.01, compared with TW