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Table 5 Absorption parameters of triptonide of various formulae in perfusate solution within duodenum, jejunum, ileum and colon (\( {\bar{\text{x}}} \pm {\text{s}} \), n = 6)

From: Different modulation of Panax notoginseng on the absorption profiling of triptolide and tripterine from Tripterygium wilfordii in rat intestine

Parameters Con. (μg/mL) Duodenum Jejunum Ileum Colon
Peff × 10−3 Triptonide 11.6 ± 2.95 8.77 ± 1.47 9.34 ± 2.92 8.40 ± 1.94
TW 13.3 ± 3.43 8.98 ± 1.26 11.3 ± 3.3 10.4 ± 2.04
TW-PN 7.86 ± 1.36** 6.12 ± 1.38** 7.05 ± 1.29* 6.6 ± 1.57**
TW-CS 12.8 ± 1.28 7.68 ± 1.64 9.93 ± 2.73 8.44 ± 1.31
QLTB 5.55 ± 0.55** 5.48 ± 1.07** 4.75 ± 1.18** 5.22 ± 1.13**
10 cm%ABS Triptonide 46.1 ± 2.89 44.9 ± 3.67 44.5 ± 3.31 45.6 ± 3.76
TW 51.2 ± 8.5 46.8 ± 5.76 47.7 ± 7.12 49.7 ± 4.5
TW-PN 40.4 ± 4.7* 33.6 ± 3.04** 37.0 ± 6.96* 35.9 ± 5.8**
TW-CS 46.8 ± 5.3 41.3 ± 4.09 44.4 ± 4.18 45.6 ± 3.1
QLTB 34.0 ± 5.7** 31.9 ± 3.27** 31.1 ± 7.18** 33.8 ± 3.4**
Ka × 10−2 Triptonide 5.64 ± 1.22 2.60 ± 0.23 1.15 ± 0.47 1.33 ± 0.66
TW 6.03 ± 1.03 2.81 ± 0.18 1.32 ± 0.55 1.53 ± 0.46
TW-PN 4.51 ± 0.83* 1.86 ± 0.14** 1.47 ± 0.68 0.99 ± 0.33*
TW-CS 2.9 ± 1.68** 1.46 ± 0.28** 1.23 ± 0.78 1.37 ± 0.49
QLTB 3.13 ± 1.11** 1.42 ± 0.08** 1.39 ± 0.36 0.70 ± 0.13**
  1. * p < 0.05, ** p < 0.01, compared with TW