Parameters | Con. (μg/mL) | Duodenum | Jejunum | Ileum | Colon |
---|---|---|---|---|---|
Peff × 10−3 | Wilforlide | 6.07 ± 2.14 | 9.57 ± 1.25 | 12.2 ± 3.14 | 9.65 ± 1.95 |
TW | 6.69 ± 1.93 | 11.6 ± 1.08# | 14.7 ± 3.51 | 12.5 ± 1.65# | |
TW-PN | 5.91 ± 1.03 | 4.41 ± 1.27** | 5.46 ± 2.79** | 9.9 ± 0.63** | |
TW-CS | 4.98 ± 1.39 | 3.89 ± 0.41** | 10.6 ± 1.27* | 4.77 ± 2.56** | |
QLTB | NA | NA | NA | NA | |
10 cm%ABS | Wilforlide | 31.3 ± 3.26 | 37.5 ± 2.47 | 41.3 ± 3.78 | 42.1 ± 4.22 |
TW | 33.2 ± 7.06 | 39.8 ± 1.51 | 43.5 ± 4.44 | 44.0 ± 3.51 | |
TW-PN | 26.2 ± 5.75 | 18.2 ± 5.69** | 21.4 ± 1.35** | 26.0 ± 4.69** | |
TW-CS | 26.8 ± 5.08 | 25.6 ± 4.16** | 35.6 ± 1.37** | 30.7 ± 1.59** | |
QLTB | NA | NA | NA | NA | |
Ka × 10−2 | Wilforlide | 1.34 ± 0.55 | 2.27 ± 0.21 | 2.53 ± 0.43 | 1.36 ± 0.12 |
TW | 1.54 ± 0.55 | 2.39 ± 0.03 | 2.73 ± 0.35 | 1.54 ± 0.19 | |
TW-PN | 1.37 ± 0.32 | 0.92 ± 0.44** | 1.18 ± 0.78** | 0.83 ± 0.39** | |
TW-CS | 1.18 ± 0.32* | 0.77 ± 0.15** | 1.21 ± 0.54** | 0.50 ± 0.33** | |
QLTB | NA | NA | NA | NA |