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Table 7 Absorption parameters of wilforlide of various formulae in perfusate solution within duodenum, jejunum, ileum and colon (\( {\bar{\text{x}}} \pm {\text{s}} \), n = 6)

From: Different modulation of Panax notoginseng on the absorption profiling of triptolide and tripterine from Tripterygium wilfordii in rat intestine

Parameters

Con. (μg/mL)

Duodenum

Jejunum

Ileum

Colon

Peff × 10−3

Wilforlide

6.07 ± 2.14

9.57 ± 1.25

12.2 ± 3.14

9.65 ± 1.95

TW

6.69 ± 1.93

11.6 ± 1.08#

14.7 ± 3.51

12.5 ± 1.65#

TW-PN

5.91 ± 1.03

4.41 ± 1.27**

5.46 ± 2.79**

9.9 ± 0.63**

TW-CS

4.98 ± 1.39

3.89 ± 0.41**

10.6 ± 1.27*

4.77 ± 2.56**

QLTB

NA

NA

NA

NA

10 cm%ABS

Wilforlide

31.3 ± 3.26

37.5 ± 2.47

41.3 ± 3.78

42.1 ± 4.22

TW

33.2 ± 7.06

39.8 ± 1.51

43.5 ± 4.44

44.0 ± 3.51

TW-PN

26.2 ± 5.75

18.2 ± 5.69**

21.4 ± 1.35**

26.0 ± 4.69**

TW-CS

26.8 ± 5.08

25.6 ± 4.16**

35.6 ± 1.37**

30.7 ± 1.59**

QLTB

NA

NA

NA

NA

Ka × 10−2

Wilforlide

1.34 ± 0.55

2.27 ± 0.21

2.53 ± 0.43

1.36 ± 0.12

TW

1.54 ± 0.55

2.39 ± 0.03

2.73 ± 0.35

1.54 ± 0.19

TW-PN

1.37 ± 0.32

0.92 ± 0.44**

1.18 ± 0.78**

0.83 ± 0.39**

TW-CS

1.18 ± 0.32*

0.77 ± 0.15**

1.21 ± 0.54**

0.50 ± 0.33**

QLTB

NA

NA

NA

NA

  1. #p < 0.05, compared with wilforlide; * p < 0.05, ** p < 0.01, compared with TW; NA none detected