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Table 7 Absorption parameters of wilforlide of various formulae in perfusate solution within duodenum, jejunum, ileum and colon (\( {\bar{\text{x}}} \pm {\text{s}} \), n = 6)

From: Different modulation of Panax notoginseng on the absorption profiling of triptolide and tripterine from Tripterygium wilfordii in rat intestine

Parameters Con. (μg/mL) Duodenum Jejunum Ileum Colon
Peff × 10−3 Wilforlide 6.07 ± 2.14 9.57 ± 1.25 12.2 ± 3.14 9.65 ± 1.95
TW 6.69 ± 1.93 11.6 ± 1.08# 14.7 ± 3.51 12.5 ± 1.65#
TW-PN 5.91 ± 1.03 4.41 ± 1.27** 5.46 ± 2.79** 9.9 ± 0.63**
TW-CS 4.98 ± 1.39 3.89 ± 0.41** 10.6 ± 1.27* 4.77 ± 2.56**
QLTB NA NA NA NA
10 cm%ABS Wilforlide 31.3 ± 3.26 37.5 ± 2.47 41.3 ± 3.78 42.1 ± 4.22
TW 33.2 ± 7.06 39.8 ± 1.51 43.5 ± 4.44 44.0 ± 3.51
TW-PN 26.2 ± 5.75 18.2 ± 5.69** 21.4 ± 1.35** 26.0 ± 4.69**
TW-CS 26.8 ± 5.08 25.6 ± 4.16** 35.6 ± 1.37** 30.7 ± 1.59**
QLTB NA NA NA NA
Ka × 10−2 Wilforlide 1.34 ± 0.55 2.27 ± 0.21 2.53 ± 0.43 1.36 ± 0.12
TW 1.54 ± 0.55 2.39 ± 0.03 2.73 ± 0.35 1.54 ± 0.19
TW-PN 1.37 ± 0.32 0.92 ± 0.44** 1.18 ± 0.78** 0.83 ± 0.39**
TW-CS 1.18 ± 0.32* 0.77 ± 0.15** 1.21 ± 0.54** 0.50 ± 0.33**
QLTB NA NA NA NA
  1. #p < 0.05, compared with wilforlide; * p < 0.05, ** p < 0.01, compared with TW; NA none detected