Skip to main content
Fig. 1 | Chinese Medicine

Fig. 1

From: Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model

Fig. 1

Bleomycin-induced SSc mouse model treated with WYHZTL formula and XAV-939 are protected against dermal fibrosis. Skin sections for histology were stained with hematoxylin and eosin (a). Representative photomicrographs are shown for each group. Differences in skin thickness (b), skinfold thickness (c), breaking tension (d) between Normal, PBS, BLM, BLM + WYHZTL-L (11.75 g/kg/day), BLM + WYHZTL-M (23.50 g/kg/day), BLM + WYHZTL-H (47.00 g/kg/day) or BLM + XAV-939 (10 mg/kg/day) groups after injections of Bleomycin (BLM) or phosphate buffered saline (PBS) for 3 weeks. The mean values ± SD (n = 8 per group) was shown for each bar. *(P < 0.05) or **(P < 0.01) or ***(P < 0.001) represents significance. Original magnification: ×20 (a). BLM: Bleomycin, WYHZTL: Wenyang Huazhuo Tongluo formula, WYHZTL-L: low-dosage of WYHZTL formula, WYHZTL-M: medium-dosage of WYHZTL formula, WYHZTL-H: high-dosage of WYHZTL formula

Back to article page