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Fig. 2 | Chinese Medicine

Fig. 2

From: Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model

Fig. 2

The ratios of the mRNA expression level of Wnt1, β-catenin, TCF4, GSK3β, DKK1, cyclin D1, survivin, CTGF, VEGF, FN1, Collagen I and Collagen III relative to that of GAPDH. The mRNA expression level ratios of Wnt1 (a), β-catenin (b), TCF4 (c), GSK3β (d), DKK1 (e), cyclin D1 (f), survivin (g), CTGF (h), VEGF (i), FN1 (j), Collagen I (k) and Collagen III (l) relative to GAPDH were calculated by RT-qPCR. The mean values ± SD (n = 8 per group) was shown for each bar. *(P < 0.05) or **(P < 0.01) or ***(P < 0.001) represents significance, ns represents no significance. BLM: Bleomycin, WYHZTL: Wenyang Huazhuo Tongluo formula, WYHZTL-L: low-dosage of WYHZTL formula, WYHZTL-M: medium-dosage of WYHZTL formula, WYHZTL-H: high-dosage of WYHZTL formula. RT-qPCR: Reverse transcription-quantitative polymerase chain reaction

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