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Table 1 Effects of triptolide on organ: body weight ratios

From: Extrahepatic cytochrome P450s play an insignificant role in triptolide-induced toxicity

Organ Mouse group Organ: body weight ratios (%)
Control 0.1 mg/kg 0.2 mg/kg
Brain Xh-CL 2.01 ± 0.13 2.17 ± 0.19 1.98 ± 0.01
WT 2.45 ± 0.13 2.44 ± 0.02 2.32 ± 0.06
Liver Xh-CL 5.67 ± 0.53 5.43 ± 0.13 6.62 ± 0.80
WT 4.94 ± 0.86 4.54 ± 0.79 7.01 ± 0.25#
Lung Xh-CL 0.64 ± 0.03 0.73 ± 0.05 0.63 ± 0.01
WT 0.65 ± 0.01 0.66 ± 0.01 0.64 ± 0.02
Kidney Xh-CL 1.41 ± 0.06 1.52 ± 0.45 1.54 ± 0.03
WT 1.40 ± 0.01 1.54 ± 0.08 1.63 ± 0.01
Spleen Xh-CL 0.34 ± 0.01 0.42 ± 0.02 0.59 ± 0.04#
WT 0.47 ± 0.02 0.34 ± 0.01 0.61 ± 0.01
Testis Xh-CL 0.87 ± 0.11 0.63 ± 0.01 0.40 ± 0.03##
WT 0.74 ± 0.04 0.57 ± 0.03 0.43 ± 0.06#
  1. Xh-CL and WT mice (n = 5 in each group) were administered with 0.1 or 0.2 mg/kg triptolide. The control mice were administered with a vehicle. Mice were dosed every other day for 30 days. Data were shown as mean ± SD
  2. #p < 0.05, ## p < 0.01 vs. control