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Table 2 Extent of tissue toxicity in Xh-CL and WT mice following triptolide

From: Extrahepatic cytochrome P450s play an insignificant role in triptolide-induced toxicity

Organ

Mouse group

Triptolide dose (mg/kg)

Number of mice in each grade

+

±

Liver

Xh-CL

0.1

0

2

3

 

0.2

1

3

1

WT

0.1

0

1

4

 

0.2

1

2

2

Kidney

Xh-CL

0.1

0

2

3

 

0.2

2

2

1

WT

0.1

0

2

3

 

0.2

1

2

2

Testis

Xh-CL

0.1

2

3

0

 

0.2

5

0

0

WT

0.1

1

4

0

 

0.2

5

0

0

Spleen

Xh-CL

0.1

0

1

4

 

0.2

2

2

1

WT

0.1

1

1

3

 

0.2

1

3

1

  1. Xh-CL and WT mice (n = 5 in each group) were treated with 0.1 or 0.2 mg/kg triptolide, mice were dosed every other day for 30 days. The severity of lesions in the tissues was graded as follows: +, moderate; ±, mild; and −, negative