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Table 3 Triptolide plasma pharmacokinetic parameters in Xh-CL and WT mice

From: Extrahepatic cytochrome P450s play an insignificant role in triptolide-induced toxicity

Group Cmax (mg/L) Tmax (min) AUC(0–t) (mg/L min) AUC(0–∞) (mg/L min) T1/2 (min) CLz/F (L/min/kg)
Xh-CL 0.145 ± 0.002 15 ± 0 2.435 ± 0.233 2.445 ± 0.275 6.411 ± 1.41 0.409 ± 0.029
WT 0.139 ± 0.004 15 ± 0 2.579 ± 0.194 2.602 ± 0.198 7.442 ± 1.64 0.384 ± 0.035
  1. Xh-CL and WT mice were administered 1.0 mg/kg triptolide orally. All data are presented as mean ± standard deviation. No significant differences were observed between the groups for any parameter (n = 3). Data were shown as mean ± SD
  2. C max maximum concentration, T max time to reach Cmax, AUC area under the curve, T 1/2 elimination half-life, CLz/F oral clearance