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Fig. 3 | Chinese Medicine

Fig. 3

From: Cellular stress response mechanisms of Rhizoma coptidis: a systematic review

Fig. 3

Molecular mechanisms of Rhizoma coptidis on MAPK pathways (—• indicates inhibition/reduction, arrow indicates promotion/stimulation). Rhizoma coptidis can modulate MAPK pathways via several pathways, including ERK, JNK and p38 pathways. Three pathways can be adjusted specifically by Rhizoma coptidis. Through modulation of various MAPK pathways, Rhizoma coptidis suppresses inflammatory responses causing by TNF-α, IL-1β and ultraviolet irradiation and inhibits of apoptosis

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