Fig. 4From: Cellular stress response mechanisms of Rhizoma coptidis: a systematic reviewMolecular mechanisms of Rhizoma coptidis on AMPK pathways (—• indicates inhibition/reduction, arrow indicates promotion/stimulation). Rhizoma coptidis can activate AMPK pathways via modulating upstream targets (i.e., LKB1). Once AMPK is activated, downstream signals of AMPK will be stimulated to demonstrate multiple biological effects, including anti-obesity, anti-diabetes, etc.Back to article page