Fig. 5

The relative expression level of TNF-α (a), TGF-β1 (b) and SMAD4 (c) in different groups by immunohistochemical staining on day 7, 14 and 28. The expression levels of TNF-α, TGF-β1 and SMAD4 were assessed by Graphic context analysis software (ImagePro plus 6.0). All data are expressed as mean ±S.D (n = 5). Results are statistically significance at p < 0.05. *p < 0.05 vs control; ^∆p < 0.05 vs BLM; ^#p < 0.05 vs BLM + DEX; ^■p < 0.05 vs BLM + LD-SML, by two-way ANOVA followed by Tukey’s multiple comparisons test. LD low-dose, MD medium-dose, HD high-dose