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Table 2 The anti-cancer effects of major components of AL

From: Pharmacological effects of medicinal components of Atractylodes lancea (Thunb.) DC.

Chemical name Tumor suppressive effect Potential targets Function study References
Atractylenolide I Anti-bladder cancer effect ↓PI3K/Akt/mTOR In vitro and In vivo [17]
  Anti-leukemia effect ↑CD14/CD68 In vitro [23]
  Anti-melanoma effect ↓p-JAK2/p-STAT3 In vitro [25]
Atractylenolide II Anti-melanoma effect ↓p-STAT3/p-Src In vitro and in vivo [33]
  Anti-gastric cancer effect ↓p-Akt/p-ERK In vitro [34]
Hinesol Anti-leukemia effect ↓c-Jun In vitro [50]
β-Eudesmol Anti-bile duct cancer effect ↓NQO1 In vitro and in vivo [53, 54]
β-Sitosterol Anti-melanoma effect ↓JNK In vitro [77]
  Anti-gastric cancer effect ↑PTEN/p-AMPK In vitro and in vivo [78]