Application of metabolomics in toxicity evaluation of traditional Chinese medicines

Chinese Medicine

Table 1 The applications of metabolomics in hepatotoxicity evaluation of TCM

TCM	Toxicity	Animals	Samples	Metabolomic technology	Data analysis	Metabolic pathways	References
Triptolide	Hepatotoxicity	Mice	Serum, liver	LC–MS	PCA, PLS-DA	Glutathione metabolism, tricarboxylic acid cycle, purine metabolism, glycerophospholipid metabolism, taurine and hypotaurine metabolism, pantothenate and coenzyme A biosynthesis, pyrimidine metabolism, amino acid metabolism	[45, 46]
Dioscorea bulbifera Rhizome	Hepatotoxicity	Rats	Plasma, urine, feces	GC–MS	OPLS-DA	Amino acid metabolism, bile acid metabolism, purine metabolism, pyrimidine metabolism, lipid metabolism, energy metabolism	[49]
Dioscorea bulbifera Rhizome	Hepatotoxicity	Rats	Urine	¹H NMR	PLS-DA	Amino acid metabolism, fatty acid metabolism, energy metabolism	[50]
Xanthii Fructus	Hepatotoxicity	Rats	Urine	LC–MS	PCA, PLS-DA, OPLS-DA	Mitochondrial inability, fatty acid metabolism, amino acids metabolism	[52, 53]
Polygoni multiflori radix	Chronic hepatotoxicity	Rats	Serum	GC–MS	PCA, PLS-DA	Amino acid metabolism, fatty acid metabolism, oxidative injury	[55]
Realgar	Hepatotoxicity	Rats	Urine	LC–MS, ¹H NMR	PCA, OPLS-DA	Citric acid cycle, tryptophan metabolism, porphyrin metabolism	[57]
Realgar	Sub-chronic hepatotoxicity	Mice	Plasma, urine	¹H NMR	PCA	Energy metabolism, amino acids metabolism, gut bacteria metabolism	[58]

ISSN: 1749-8546