Skip to main content

Table 1 The applications of metabolomics in hepatotoxicity evaluation of TCM

From: Application of metabolomics in toxicity evaluation of traditional Chinese medicines

TCM Toxicity Animals Samples Metabolomic technology Data analysis Metabolic pathways References
Triptolide Hepatotoxicity Mice Serum, liver LC–MS PCA, PLS-DA Glutathione metabolism, tricarboxylic acid cycle, purine metabolism, glycerophospholipid metabolism, taurine and hypotaurine metabolism, pantothenate and coenzyme A biosynthesis, pyrimidine metabolism, amino acid metabolism [45, 46]
Dioscorea bulbifera Rhizome Hepatotoxicity Rats Plasma, urine, feces GC–MS OPLS-DA Amino acid metabolism, bile acid metabolism, purine metabolism, pyrimidine metabolism, lipid metabolism, energy metabolism [49]
Rats Urine 1H NMR PLS-DA Amino acid metabolism, fatty acid metabolism, energy metabolism [50]
Xanthii Fructus Hepatotoxicity Rats Urine LC–MS PCA, PLS-DA, OPLS-DA Mitochondrial inability, fatty acid metabolism, amino acids metabolism [52, 53]
Polygoni multiflori radix Chronic hepatotoxicity Rats Serum GC–MS PCA, PLS-DA Amino acid metabolism, fatty acid metabolism, oxidative injury [55]
Realgar Hepatotoxicity Rats Urine LC–MS, 1H NMR PCA, OPLS-DA Citric acid cycle, tryptophan metabolism, porphyrin metabolism [57]
Sub-chronic hepatotoxicity Mice Plasma, urine 1H NMR PCA Energy metabolism, amino acids metabolism, gut bacteria metabolism [58]