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Table 4 The applications of metabolomics in other toxicity evaluation of TCM

From: Application of metabolomics in toxicity evaluation of traditional Chinese medicines

TCM

Toxicity

Animals

Samples

Metabolomic technology

Data analysis

Metabolic pathways

References

Triptolide

Reproduction toxicity

Mice

Serum, testis

GC–MS

PLS-DA

Lipid metabolism, energy metabolism

[85]

Cinnabar

Neurotoxicity

Rats

Brain

1H NMR

PCA

Glutamate metabolism, membrane disruption, energy metabolism, oxidative injury

[87]

Kunsui Radix

Inflammation, irritation to the skin, tumor-promotion

Rats

Urine

1H NMR

PCA

Tricarboxylic acid cycle, anaerobic glycolysis, amino acids metabolism

[89]

Coptidis Rhizome

Diarrhea

Rats

Serum, urine

1H NMR, GC–MS

PCA, OPLS-DA

Gut microflora metabolism, energy metabolism, amino acids metabolism

[90]

Niuhuang Jiedu Tablet

Hepatotoxicity, nephrotoxicity

Rats

Urine

1H NMR

PCA, PLS-DA

Energy metabolism, choline metabolism, amino acid metabolism, gut flora disorder

[92]

Zhusha Anshen Wan

Hepatotoxicity, nephrotoxicity

Rats

Serum, urine

1H NMR

PLS-DA

Energy metabolism, lipid metabolism, choline metabolism

[93]

Shuanghuanglian injection

Hemolytic anemia

Dogs

Serum

1H NMR

PCA

Cell membranes metabolism, lipid metabolism, energy metabolism, amino acid metabolism, gut microflora metabolism

[95]