Table 2 Metabolomics approach on TCMs-derived compounds or aqueous extracts in treatment of viral pneumonia in animal models
From: Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine
Herbs | Compounds/part used | Virus type | Sample material | Detection method | Metabolomics validation (treatment group vs. model group) | References |
|---|---|---|---|---|---|---|
Scutellaria baicalensis Georgi | Baicalein | RSV | HEP-2 Cell | GC–MS | Upregulate: Serine, Aspartic acid, Glutamic acid, Citric acid, Glycine | [12] |
Plasma | Upregulate: Lactic acid, Urea, 1,5-Sorbitan Downregulate: Glycine, Glutamine, d-glucose | |||||
Urine | Downregulate: Lactic acid, Malic acid, Palmitic acid, Stearic acid | |||||
BALF | LC–MS | Upregulate: Glutamate, O-octadecenoyl-carnitine, Adenosine, Glucosylceramide, Downregulate: Leukotriene D5 | ||||
Scutellaria baicalensis Georgi | Root | RSV | Plasma | LC–MS | Upregulate: LysoPC(16:0), LysoPC(18:0), LysoPC(20:4), SM(d18:1/24:1), LysoPC(18:2) | [13] |
Lung | Upregulate: TG(18:1/18:2/18:2), TG(18:1/18:1/18:2), TG(18:1/18:1/18:1), PC(16:0/18:1) | |||||
Polygonum cuspidatum Sieb. Et Zucc | Rootstalk and root | RSV | Plasma | LC–MS | Upregulate: LysoPC(14:0), LysoPC(15:0), LysoPC(18:2), LysoPC(17:1), LysoPC(16:0), LysoPC(18:1), LysoPC(18:0), CerP(d13:0/26:3), PC(18:0p/16:0), PC(16:0/18:0), CerP(d15:0/32:3), TG(18:0/18:1/20:1), TG(20:1/18:1/22:0) Pathway: Phospholipid metabolism | [14] |
Flos Lonicerae Japonica and Fructus Forsythiae | Flower; Fruit | H1N1 | Plasma | GC–MS | Downregulate: 3–4-Dihydroxycinnamic acid, Betamannosylglycerate, Glycine, Hydrocinnamic acid Pathway: Galactose metabolism”; “Glycine, serine and threonine metabolism”; “Synthesis and degradation of ketone bodies” | [59] |