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Fig. 2 | Chinese Medicine

Fig. 2

From: Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells in a P-gp-independent manner through enhanced ROS generation

Fig. 2

Effect of SKN, PTX or their combinations on cell apoptosis of A2780 and A2780/PTX cells. A2780 (a) or A2780/PTX (b) Cells (2 × 105/well) were treated with SKN (1 μM), PTX (1 μM) or their combinations for 24 h, followed by staining with Annexin V-FITC/PI and flow cytometry analysis. Annexin-V-FITC+/PI cells in Quadrant 4 (Q4) and Annexin-V-FITC+/PI+ cells in Quadrant 2 (Q2) were considered as early and late apoptotic cells, respectively. Apoptosis rate (%) of A2780 (c) and A2780/PTX (d) cells was calculated as early and late apoptotic cell population

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