Fig. 4From: Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells in a P-gp-independent manner through enhanced ROS generationCombination of SKN and PTX promotes ROS generation, and pretreatment of NAC reverses SKN/PTX-induced ROS promotion. A2780 (a) or A2780/PTX (b) cells were seeded (6 × 104/well) and treated with NAC (5 mM), SKN (1 μM), PTX (1 μM), or their combinations as specified for 4 h. The cells were stained with 1 μM CM-H2DCFDA for 30 min at 37 °C and analyzed by flow cytometryBack to article page