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Table 3 Natural anti-biofilm agents under clinical evaluation (http://clinicaltrials.gov/)

From: Developing natural products as potential anti-biofilm agents

Condition Status Intervention Phase Year
Biofilms
Essential oils
Periodontitis
Not yet recruiting Drug: Essential oils
Drug: Essential oils without alcohol
Drug: Sterile water
IV 2016
Biofilms
Substantivity
Essential oils
Not yet recruiting Drug: Essential oils
Drug: Essential oils without mouthwash
Drug: Sterile water
IV 2016
Oral biofilm
Dental plaque
Periodontitis
Recruiting Drug: Essential oils
Drug: Alcohol free essential oils
Other: Water
IV 2017
Streptococcal infections
Saliva altered
Completed Other: Propolis varnish I and II 2015
Gingivitis Completed Dietary supplement: Black tea
Dietary supplement: Green tea
Drug: 0.12% chlorhexidine mouthwash
III 2015
Oral biofilm
Mouthwash
Periodontitis
Completed Drug: Essential oils
Drug: 0.2% chlorhexidine
Drug: Sterile water
IV 2013
Dental biofilm pH Completed Other: G1, G2 and G3
Other: G4 and G5
II 2012
Gingivitis Completed Drug: Punica granatum Linn.
Drug: chlorhexidine
Not applicable 2012
Prostheses-related infections Completed Other: Physiological solution
Other: Sodium hypochlorite
Other: Alkaline peroxide
Other: Castor bean solution
Not applicable 2011