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Fig. 3 | Chinese Medicine

Fig. 3

From: Identifying the functions and biomarkers of Codonopsis pilosula and Astragalus membranaceus aqueous extracts in hepatic cells

Fig. 3

Identification of differentially expressed genes in HepG2 cells treated with C. pilosula and A. membranaceus. a Volcano plots of HepG2 cells treated with C. pilosula for 24 h at a dose of 3 mg/mL. Total RNA was extracted and genomic profiling was performed using Illumina Human HT-12 v4 BeadChips. The red spots represent probes with fold changes ≥ 1.5× and P < 0.05, whereas the green spots represent probes with fold changes < 1.5× and P < 0.05. b Volcano plots of HepG2 cells treated with A. membranaceus for 24 h at a dose of 3 mg/mL. The orange–red spots represent probes with fold changes > 1.5× and P < 0.05, whereas the blue spots represent probes with fold changes < 1.5× and P < 0.05. c Venn diagram of differentially expressed probes. The blue circle represents probes identified from HepG2 cells treated with C. pilosula. The green circle represents probes identified from cells treated with A. membranaceus. d Principal component analysis of cells treated with C. pilosula or A. membranaceus with the common differentially expressed probes (n = 67). Blue spot: C. pilosula treatment; green spot: A. membranaceus treatment; black spot: non-treated control. e Heatmap and hierarchical cluster analysis of differentially expressed probes responsive to both C. pilosula and A. membranaceus treatment. Upregulated and downregulated probes are denoted in red and green, respectively

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