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Table 3 Up-regulated proteins with a fold change ≥ 1.5 and ≤ 2.0 under GZZSZTW treatment (GZZSZTW vs. Blank)

From: Dissection of the molecular targets and signaling pathways of Guzhi Zengsheng Zhitongwan based on the analysis of serum proteomics

Protein name

Fold change

p value

Protein FAM50B (FAM50B)

2.00

0

Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A)

2.00

0

Elongation factor 1-gamma (EEF1G)

1.98

0

Serine/threonine-protein kinase TAO3 (TAOK3)

1.98

0.03

Cell division control protein 42 homolog (CDC42)

1.98

0

Ras-related protein Rab-27B (RAB27B)

1.97

0

Protein S100-A9 (S100A9)

1.97

0.01

cGMP-specific 3′,5′-cyclic phosphodiesterase (PDE5A)

1.96

0.01

Pyruvate kinase PKM (PKM)

1.96

0

Pyrethroid hydrolase Ces2e (CES2E)

1.95

0.01

Coronin-1B (CORO1B)

1.95

0

T-complex protein 1 subunit epsilon (CCT5)

1.93

0

Caveolae-associated protein 2 (CAVIN2)

1.93

0

Septin-9 (SEPT9)

1.93

0.04

14-3-3 protein eta (YWHAH)

1.92

0

Regulator of G-protein signaling 18 (RGS18)

1.92

0.04

Heat shock cognate 71 kDa protein (HSPA8)

1.92

0

Talin-1 (TLN1)

1.92

0

Ras-related protein Rap-1b (RAP1B)

1.92

0

Src kinase-associated phosphoprotein 2 (SKAP2)

1.91

0

Glucose-6-phosphate 1-dehydrogenase (G6PDX)

1.91

0

UMP-CMP kinase (CMPK1)

1.89

0

Guanylate cyclase soluble subunit beta-1 (GUCY1B3)

1.88

0.01

Glutathione peroxidase 1 (GPX1)

1.88

0

Serine/threonine-protein kinase 26 (STK26)

1.88

0

Chloride intracellular channel protein 1 (CLIC1)

1.88

0

Vitamin D-binding protein (GC)

1.88

0

14-3-3 protein zeta/delta (YWHAZ)

1.88

0

Tubulin beta-7 chain (TUBB7)

1.87

0

Tubulin alpha-1C chain (TUBA1C)

1.86

0

Tubulin beta-2A chain (TUBB2A)

1.86

0

Galectin-1 (LGALS1)

1.85

0

Myosin regulatory light chain RLC-A (RLCA)

1.85

0

Eukaryotic translation initiation factor 5A-2 (EIF5A2)

1.84

0

Dynamin-2 (DNM2)

1.84

0

T-complex protein 1 subunit beta (CCT2)

1.83

0

Tropomyosin alpha-4 chain (TPM4)

1.82

0

Alpha-soluble NSF attachment protein (NAPA)

1.81

0

Elongation factor 1-delta (EEF1D)

1.80

0

Peroxiredoxin-1 (PRDX1)

1.80

0

Vinculin (VCL)

1.79

0

Tropomyosin beta chain (TPM2)

1.79

0

Arachidonate 12-lipoxygenase, 12S-type (ALOX12)

1.78

0

Serine protease inhibitor A3 M (SERPINA3 M)

1.77

0

Creatine kinase B-type (CKB)

1.76

0

Alpha-centractin (ACTR1A)

1.76

0

Renin receptor (ATP6AP2)

1.75

0

Nuclear receptor-binding protein (NRBP1)

1.75

0.01

Tyrosine-protein kinase Lyn (LYN)

1.73

0.03

Cytosol aminopeptidase (LAP3)

1.72

0.01

UV excision repair protein RAD23 homolog A (RAD23A)

1.72

0.01

Tropomyosin alpha-1 chain (TPM1)

1.71

0.01

Tubulin beta-1 chain (TUBB1)

1.70

0

Ras-related protein Rab-11B (RAB11B)

1.70

0

T-complex protein 1 subunit eta (CCT7)

1.69

0.01

Integrin-linked protein kinase (ILK)

1.69

0

Eukaryotic peptide chain release factor subunit 1 (ETF1)

1.69

0.02

Ras-related protein Rab-15 (RAB15)

1.68

0

T-complex protein 1 subunit gamma (CCT3)

1.68

0

cGMP-specific 3′,5′-cyclic phosphodiesterase (PDE5A)

1.67

0

Creatine kinase M-type (CKM)

1.67

0

Ras-related protein Rab-35 (RAB35)

1.67

0

Xaa-Pro aminopeptidase 1 (XPNPEP1)

1.66

0

GTP-binding nuclear protein Ran (RAN)

1.65

0

Moesin (MSN)

1.65

0

Class I histocompatibility antigen, Non-RT1.A alpha-1 chain (RT1AW2)

1.63

0

Glycogen phosphorylase, liver form (PYGL)

1.63

0

Transforming protein RhoA (RHOA)

1.63

0

Ras suppressor protein 1 (RSU1)

1.63

0.01

Ras GTPase-activating protein 3 (RASA3)

1.62

0

Myosin light polypeptide 6 (MYL6)

1.62

0

Actin, cytoplasmic 2 (ACTG1)

1.61

0

Lipopolysaccharide-binding protein (LBP)

1.60

0

l-lactate dehydrogenase A chain (LDHA)

1.60

0

Protein diaphanous homolog 1 (DIAPH1)

1.60

0.01

T-complex protein 1 subunit delta (CCT4)

1.60

0

cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B)

1.60

0

Ubiquitin carboxyl-terminal hydrolase 5 (USP5)

1.59

0

Ras-related protein Rab-1B (RAB1B)

1.57

0.02

Cytosolic non-specific dipeptidase (CNDP2)

1.57

0

Protein S100-A8 (S100A8)

1.56

0.01

PDZ domain-containing protein GIPC1 (GIPC1)

1.56

0.02

Fermitin family homolog 3 (FERMT3)

1.56

0

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

1.56

0

Ras-related C3 botulinum toxin substrate 1 (RAC1)

1.55

0

Myosin-9 (MYH9)

1.55

0

Tropomyosin alpha-3 chain (TPM3)

1.55

0

AP-1 complex subunit beta-1 (AP1B1)

1.54

0

T-complex protein 1 subunit alpha (TCP1)

1.54

0

RAS guanyl-releasing protein 2 (RASGRP2)

1.53

0

Myosin light chain kinase, smooth muscle (MYLK)

1.53

0

Keratin, type II cytoskeletal 1 (KRT1)

1.52

0

Myosin regulatory light polypeptide 9 (MYL9)

1.52

0

Inhibin beta C chain (INHBC)

1.51

0

Ubiquitin-like modifier-activating enzyme 1 (UBA1)

1.51

0

14-3-3 protein beta/alpha (YWHAB)

1.50

0

Transforming growth factor beta-1 (TGFB1)

1.50

0