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Table 3 Up-regulated proteins with a fold change ≥ 1.5 and ≤ 2.0 under GZZSZTW treatment (GZZSZTW vs. Blank)

From: Dissection of the molecular targets and signaling pathways of Guzhi Zengsheng Zhitongwan based on the analysis of serum proteomics

Protein name Fold change p value
Protein FAM50B (FAM50B) 2.00 0
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) 2.00 0
Elongation factor 1-gamma (EEF1G) 1.98 0
Serine/threonine-protein kinase TAO3 (TAOK3) 1.98 0.03
Cell division control protein 42 homolog (CDC42) 1.98 0
Ras-related protein Rab-27B (RAB27B) 1.97 0
Protein S100-A9 (S100A9) 1.97 0.01
cGMP-specific 3′,5′-cyclic phosphodiesterase (PDE5A) 1.96 0.01
Pyruvate kinase PKM (PKM) 1.96 0
Pyrethroid hydrolase Ces2e (CES2E) 1.95 0.01
Coronin-1B (CORO1B) 1.95 0
T-complex protein 1 subunit epsilon (CCT5) 1.93 0
Caveolae-associated protein 2 (CAVIN2) 1.93 0
Septin-9 (SEPT9) 1.93 0.04
14-3-3 protein eta (YWHAH) 1.92 0
Regulator of G-protein signaling 18 (RGS18) 1.92 0.04
Heat shock cognate 71 kDa protein (HSPA8) 1.92 0
Talin-1 (TLN1) 1.92 0
Ras-related protein Rap-1b (RAP1B) 1.92 0
Src kinase-associated phosphoprotein 2 (SKAP2) 1.91 0
Glucose-6-phosphate 1-dehydrogenase (G6PDX) 1.91 0
UMP-CMP kinase (CMPK1) 1.89 0
Guanylate cyclase soluble subunit beta-1 (GUCY1B3) 1.88 0.01
Glutathione peroxidase 1 (GPX1) 1.88 0
Serine/threonine-protein kinase 26 (STK26) 1.88 0
Chloride intracellular channel protein 1 (CLIC1) 1.88 0
Vitamin D-binding protein (GC) 1.88 0
14-3-3 protein zeta/delta (YWHAZ) 1.88 0
Tubulin beta-7 chain (TUBB7) 1.87 0
Tubulin alpha-1C chain (TUBA1C) 1.86 0
Tubulin beta-2A chain (TUBB2A) 1.86 0
Galectin-1 (LGALS1) 1.85 0
Myosin regulatory light chain RLC-A (RLCA) 1.85 0
Eukaryotic translation initiation factor 5A-2 (EIF5A2) 1.84 0
Dynamin-2 (DNM2) 1.84 0
T-complex protein 1 subunit beta (CCT2) 1.83 0
Tropomyosin alpha-4 chain (TPM4) 1.82 0
Alpha-soluble NSF attachment protein (NAPA) 1.81 0
Elongation factor 1-delta (EEF1D) 1.80 0
Peroxiredoxin-1 (PRDX1) 1.80 0
Vinculin (VCL) 1.79 0
Tropomyosin beta chain (TPM2) 1.79 0
Arachidonate 12-lipoxygenase, 12S-type (ALOX12) 1.78 0
Serine protease inhibitor A3 M (SERPINA3 M) 1.77 0
Creatine kinase B-type (CKB) 1.76 0
Alpha-centractin (ACTR1A) 1.76 0
Renin receptor (ATP6AP2) 1.75 0
Nuclear receptor-binding protein (NRBP1) 1.75 0.01
Tyrosine-protein kinase Lyn (LYN) 1.73 0.03
Cytosol aminopeptidase (LAP3) 1.72 0.01
UV excision repair protein RAD23 homolog A (RAD23A) 1.72 0.01
Tropomyosin alpha-1 chain (TPM1) 1.71 0.01
Tubulin beta-1 chain (TUBB1) 1.70 0
Ras-related protein Rab-11B (RAB11B) 1.70 0
T-complex protein 1 subunit eta (CCT7) 1.69 0.01
Integrin-linked protein kinase (ILK) 1.69 0
Eukaryotic peptide chain release factor subunit 1 (ETF1) 1.69 0.02
Ras-related protein Rab-15 (RAB15) 1.68 0
T-complex protein 1 subunit gamma (CCT3) 1.68 0
cGMP-specific 3′,5′-cyclic phosphodiesterase (PDE5A) 1.67 0
Creatine kinase M-type (CKM) 1.67 0
Ras-related protein Rab-35 (RAB35) 1.67 0
Xaa-Pro aminopeptidase 1 (XPNPEP1) 1.66 0
GTP-binding nuclear protein Ran (RAN) 1.65 0
Moesin (MSN) 1.65 0
Class I histocompatibility antigen, Non-RT1.A alpha-1 chain (RT1AW2) 1.63 0
Glycogen phosphorylase, liver form (PYGL) 1.63 0
Transforming protein RhoA (RHOA) 1.63 0
Ras suppressor protein 1 (RSU1) 1.63 0.01
Ras GTPase-activating protein 3 (RASA3) 1.62 0
Myosin light polypeptide 6 (MYL6) 1.62 0
Actin, cytoplasmic 2 (ACTG1) 1.61 0
Lipopolysaccharide-binding protein (LBP) 1.60 0
l-lactate dehydrogenase A chain (LDHA) 1.60 0
Protein diaphanous homolog 1 (DIAPH1) 1.60 0.01
T-complex protein 1 subunit delta (CCT4) 1.60 0
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) 1.60 0
Ubiquitin carboxyl-terminal hydrolase 5 (USP5) 1.59 0
Ras-related protein Rab-1B (RAB1B) 1.57 0.02
Cytosolic non-specific dipeptidase (CNDP2) 1.57 0
Protein S100-A8 (S100A8) 1.56 0.01
PDZ domain-containing protein GIPC1 (GIPC1) 1.56 0.02
Fermitin family homolog 3 (FERMT3) 1.56 0
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) 1.56 0
Ras-related C3 botulinum toxin substrate 1 (RAC1) 1.55 0
Myosin-9 (MYH9) 1.55 0
Tropomyosin alpha-3 chain (TPM3) 1.55 0
AP-1 complex subunit beta-1 (AP1B1) 1.54 0
T-complex protein 1 subunit alpha (TCP1) 1.54 0
RAS guanyl-releasing protein 2 (RASGRP2) 1.53 0
Myosin light chain kinase, smooth muscle (MYLK) 1.53 0
Keratin, type II cytoskeletal 1 (KRT1) 1.52 0
Myosin regulatory light polypeptide 9 (MYL9) 1.52 0
Inhibin beta C chain (INHBC) 1.51 0
Ubiquitin-like modifier-activating enzyme 1 (UBA1) 1.51 0
14-3-3 protein beta/alpha (YWHAB) 1.50 0
Transforming growth factor beta-1 (TGFB1) 1.50 0