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Table 2 Effects of different fractions of Zhimu on the immobility time of ICR mice in FST and TST

From: Identifying the active components of Baihe–Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests

Groups

Dosage (mg/kg)

Immobility time (mean ± SD, s)

FST

TST

Control

134.3 ± 22.1

118.6 ± 18.1

Fluoxetine

10

82.0 ± 21.3**

69.5 ± 21.5*

SZ

21.2

86.8 ± 18.2**

70.0 ± 21.1*

PZ

21.2

104.6 ± 27.7

102.6 ± 24.5

XZ

21.2

119.3 ± 19.9

105.3 ± 26.3

  1. SZ, PZ and XZ represented saponins of Zhimu, polysaccharides of Zhimu and xanthones of Zhimu, respectively
  2. FST and TST represented forced swimming test and tail suspension test, respectively
  3. * P < 0.05 and ** P < 0.01 compared with control group