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Table 2 Effects of different fractions of Zhimu on the immobility time of ICR mice in FST and TST

From: Identifying the active components of Baihe–Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests

Groups Dosage (mg/kg) Immobility time (mean ± SD, s)
FST TST
Control 134.3 ± 22.1 118.6 ± 18.1
Fluoxetine 10 82.0 ± 21.3** 69.5 ± 21.5*
SZ 21.2 86.8 ± 18.2** 70.0 ± 21.1*
PZ 21.2 104.6 ± 27.7 102.6 ± 24.5
XZ 21.2 119.3 ± 19.9 105.3 ± 26.3
  1. SZ, PZ and XZ represented saponins of Zhimu, polysaccharides of Zhimu and xanthones of Zhimu, respectively
  2. FST and TST represented forced swimming test and tail suspension test, respectively
  3. * P < 0.05 and ** P < 0.01 compared with control group