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Table 3 The PK parameters of five major components of Zhimu in the portal vein plasma, liver, systemic plasma and brain (containing hippocampus and cerebellum) after oral administration of BZD at 15 g/kg in rats (n = 5)

From: Identifying the active components of Baihe–Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests

PK parameters Mangiferin Neomangiferin Timosaponin AIII
Portal vein plasma Systemic plasma Portal vein plasma Systemic plasma Portal vein plasma Systemic plasma
T1/2 (h) 4.08 7.70 0.93 1.33 10.33 11.16
Tmax (h) 1.00 1.00 0.25 0.25 4.00 4.00
Cmax (ng/mL or ng/g) 1757.12 ± 219.18 889.36 ± 191.49 64.64 ± 12.00 125.28 ± 15.12 61.79 ± 25.59 16.04 ± 5.16
AUC0–t (ng/mL or ng/g) 4020.89 ± 397.02 4217.27 ± 177.38 34.36 ± 2.60 78.15 ± 5.66 582.66 ± 104.67 156.12 ± 21.63
ER − 4.88% − 127.44% 73.20%
PK parameters Timosaponin BII Timosaponin BIII   
Portal vein plasma Systemic plasma Portal vein plasma Systemic plasma
T1/2 (h) 118.97 35.78 16.59 22.82   
Tmax (h) 0.25 0.25 0.25 0.25   
Cmax (ng/mL or ng/g) 880.38 ± 159.95 276.76 ± 48.41 226.39 ± 43.92 114.14 ± 13.38   
AUC0–t (ng/mL or ng/g) 1094.92 ± 183.89 975.80 ± 253.95 369.20 ± 74.63 326.47 ± 54.29   
ER 10.88%   11.57%    
PK parameters Mangiferin Neomangiferin Timosaponin AIII Timosaponin BII Timosaponin BIII  
Liver Liver Liver Liver Liver
T1/2 (h) 59.13 13.47 12.18 116.03 13.81  
Tmax (h) 2.00 10.00 20.00 0.08 0.08  
Cmax (ng/mL or ng/g) 130.59 ± 9.76 43.15 ± 2.51 9361.26 ± 243.85 301.69 ± 102.09 158.66 ± 22.12  
AUC0–t (ng/mL or ng/g) 2520.63 ± 118.68 751.52 ± 87.96 199,598.41 ± 7787.31 6518.05 ± 411.22 859.42 ± 120.72  
PK parameters Timosaponin B II Timosaponin BII Timosaponin BIII Timosaponin BIII   
Hippocampus Cerebellum Hippocampus Cerebellum
T1/2 (h) 27.41 16.17 1.52 20.65   
Tmax (h) 10.00 0.25 1.00 0.25   
Cmax (ng/mL or ng/g) 371.90 ± 153.80 1168.66 ± 93.39 198.23 ± 122.31 349.41 ± 34.90   
AUC0–t (ng/mL or ng/g) 9093.43 ± 1034.21 11,816.11 ± 1035.46 2559.67 ± 928.52 3422.98 ± 373.46