Variables
|
Levels
|
---|
Independent variables
|
− α
|
− 1
|
0
|
+ 1
|
+ α
|
X1: shunxinzufang extract (%)
|
30.76
|
32
|
35
|
38
|
39.24
|
X2: HPMC/starch ratio
|
0.59:1
|
1:1
|
2:1
|
3:1
|
3.41:1
|
- Y1, Y2 and Y3 represent cumulative release of paeoniflorin at 2 h, 6 h, 12 h (%); Y4, Y5 and Y6 represent cumulative release of calycosin-7-glucoside at 2 h, 6 h, 12 h (%); Y7, Y8 and Y9 represent cumulative release of ferulic acid at 2 h, 6 h, 12 h (%)
Dependent variables
|
Response range
|
---|
Y1,Y4,Y7 (%)
|
Minimize
|
Y2,Y5,Y8 (%)
|
Target = 50
|
Y3,Y6,Y9 (%)
|
Maximize
|
- Y1, Y2 and Y3 represent cumulative release of paeoniflorin at 2 h, 6 h, 12 h (%); Y4, Y5 and Y6 represent cumulative release of calycosin-7-glucoside at 2 h, 6 h, 12 h (%); Y7, Y8 and Y9 represent cumulative release of ferulic acid at 2 h, 6 h, 12 h (%)