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Table 1 Variables in central composite design experiments

From: Preparation, optimization and in vitro–in vivo evaluation of Shunxin sustained release granules

Variables Levels
Independent variables − α − 1 0 + 1 + α
X1: shunxinzufang extract (%) 30.76 32 35 38 39.24
X2: HPMC/starch ratio 0.59:1 1:1 2:1 3:1 3.41:1
  1. Y1, Y2 and Y3 represent cumulative release of paeoniflorin at 2 h, 6 h, 12 h (%); Y4, Y5 and Y6 represent cumulative release of calycosin-7-glucoside at 2 h, 6 h, 12 h (%); Y7, Y8 and Y9 represent cumulative release of ferulic acid at 2 h, 6 h, 12 h (%)
Dependent variables Response range
Y1,Y4,Y7 (%) Minimize
Y2,Y5,Y8 (%) Target = 50
Y3,Y6,Y9 (%) Maximize
  1. Y1, Y2 and Y3 represent cumulative release of paeoniflorin at 2 h, 6 h, 12 h (%); Y4, Y5 and Y6 represent cumulative release of calycosin-7-glucoside at 2 h, 6 h, 12 h (%); Y7, Y8 and Y9 represent cumulative release of ferulic acid at 2 h, 6 h, 12 h (%)