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Table 1 Variables in central composite design experiments

From: Preparation, optimization and in vitro–in vivo evaluation of Shunxin sustained release granules

Variables

Levels

Independent variables

− α

− 1

0

+ 1

+ α

X1: shunxinzufang extract (%)

30.76

32

35

38

39.24

X2: HPMC/starch ratio

0.59:1

1:1

2:1

3:1

3.41:1

Dependent variables

Response range

Y1,Y4,Y7 (%)

Minimize

Y2,Y5,Y8 (%)

Target = 50

Y3,Y6,Y9 (%)

Maximize

  1. Y1, Y2 and Y3 represent cumulative release of paeoniflorin at 2 h, 6 h, 12 h (%); Y4, Y5 and Y6 represent cumulative release of calycosin-7-glucoside at 2 h, 6 h, 12 h (%); Y7, Y8 and Y9 represent cumulative release of ferulic acid at 2 h, 6 h, 12 h (%)
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Chinese Medicine

ISSN: 1749-8546

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