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Table 6 Pharmacokinetic parameters

From: Preparation, optimization and in vitro–in vivo evaluation of Shunxin sustained release granules

  Paeoniflorin Calycosin-7-glucoside Ferulic acid
Extract Granule Extract Granule Extract Granule
Cmax (μg/mL) 9.32 ± 2.47 11.37 ± 2.30 6.90 ± 2.93 8.89 ± 2.15 3.90 ± 4.68 32.37 ± 4.10
Tmax (h) 6 ± 1.63 9.5 ± 1.00 6 ± 0.00 10 ± 1.63 6.5 ± 1.00 9.5 ± 1.00
AUC (0 − t) (μg/mL h) 67.99 ± 10.89 162.72 ± 49.11 36.58 ± 13.81 114.07 ± 29.92 215.41 ± 22.43 553.17 ± 52.30
AUC (0 − ∞) (μg/mL h) 73.54 ± 7.39 190.71 ± 86.77 37.62 ± 13.84 146.20 ± 60.82 232.18 ± 15.73 659.68 ± 82.83
MRT (0 − t) (h) 5.80 ± 0.32 14.12 ± 1.98 5.76 ± 0.18 13.85 ± 2.89 5.82 ± 0.15 14.33 ± 0.25
MRT (0 − ∞) (h) 6.57 ± 0.87 18.64 ± 9.17 6.02 ± 0.22 21.86 ± 11.03 6.53 ± 0.45 20.72 ± 3.24
t1/2 (h) 2.10 ± 0.80 9.47 ± 6.92 1.55 ± 0.49 12.89 ± 7.00 2.04 ± 0.72 12.10 ± 3.13