Table 6 Pharmacokinetic parameters
From: Preparation, optimization and in vitro–in vivo evaluation of Shunxin sustained release granules
Paeoniflorin | Calycosin-7-glucoside | Ferulic acid | ||||
|---|---|---|---|---|---|---|
Extract | Granule | Extract | Granule | Extract | Granule | |
Cmax (μg/mL) | 9.32 ± 2.47 | 11.37 ± 2.30 | 6.90 ± 2.93 | 8.89 ± 2.15 | 3.90 ± 4.68 | 32.37 ± 4.10 |
Tmax (h) | 6 ± 1.63 | 9.5 ± 1.00 | 6 ± 0.00 | 10 ± 1.63 | 6.5 ± 1.00 | 9.5 ± 1.00 |
AUC (0 − t) (μg/mL h) | 67.99 ± 10.89 | 162.72 ± 49.11 | 36.58 ± 13.81 | 114.07 ± 29.92 | 215.41 ± 22.43 | 553.17 ± 52.30 |
AUC (0 − ∞) (μg/mL h) | 73.54 ± 7.39 | 190.71 ± 86.77 | 37.62 ± 13.84 | 146.20 ± 60.82 | 232.18 ± 15.73 | 659.68 ± 82.83 |
MRT (0 − t) (h) | 5.80 ± 0.32 | 14.12 ± 1.98 | 5.76 ± 0.18 | 13.85 ± 2.89 | 5.82 ± 0.15 | 14.33 ± 0.25 |
MRT (0 − ∞) (h) | 6.57 ± 0.87 | 18.64 ± 9.17 | 6.02 ± 0.22 | 21.86 ± 11.03 | 6.53 ± 0.45 | 20.72 ± 3.24 |
t1/2 (h) | 2.10 ± 0.80 | 9.47 ± 6.92 | 1.55 ± 0.49 | 12.89 ± 7.00 | 2.04 ± 0.72 | 12.10 ± 3.13 |