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Table 1 Coded and uncoded values of parameters

From: The development of an herbal material quality control strategy considering the effects of manufacturing processes

Process Parameters Symbols Coded values
− 1 0 1
Ethanol extraction Ethanol solution concentration for extraction (v/v %) X1 80 85 90
Extraction time (h) X2 6.0 8.0 10.0
Ethanol solution volume (mL) X3 600 800 1000
Concentration Volume of concentrated extract (mL) X4 100 150 200
Water precipitation Water added for water precipitation (mL) X5 300 400 500
Column chromatography Sampling flow rate (BV/h) X6 1.0 1.5 2.0
Washing flow rate (BV/h) X7 1.0 1.5 2.0
Water volume (BV) X8 1.0 2.0 3.0
Ethanol solution concentration for elution (v/v %) X9 55 60 65
Elution time (min) X10 120 150 180