Primary analysis | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Acupuncture and herbal moxibustion (N = 32) | Acupuncture (N = 32) | Waiting list (N = 32) | Acupuncture and herbal moxibustion vs. acupuncture | Acupuncture and herbal moxibustion vs. waiting list | Acupuncture vs. waiting list | P-value+ | |||||||
n mean (SD) | n mean (SD) | n mean (SD) | β (95% CI) | P-value* | β (95% CI) | P-value* | β (95% CI) | P-value* | |||||
TNSS score | < 0.01 | ||||||||||||
Weeks 4 | 29 | 4.7 (2.7) | 30 | 5.1 (3.0) | 29 | 8.4 (3.0) | − 0.6 (− 2.1 ~ 0.9) | 0.42 | − 4.6 (− 6.1 ~ − 3.1) | < 0.001 | − 4.0 (− 5.4 ~ − 2.5) | < 0.001 | |
Weeks 8 | 29 | 6.2 (2.9) | 30 | 5.7 (3.0) | 28 | 8.2 (3.9) | 0.4 (− 1.3 ~ 2.1) | 0.67 | − 2.8 (− 4.6 ~ − 1.1) | 0.002 | − 3.2 (− 5.0 ~ − 1.4) | < 0.001 | |
RQLQ score | < 0.01 | ||||||||||||
Weeks 4 | 29 | 1.56 (0.85) | 30 | 1.71 (1.19) | 29 | 2.32 (0.97) | − 0.3 (− 0.8 ~ 0.2) | 0.22 | − 1.1 (− 0.7 ~ − 1.6) | < 0.001 | − 0.8 (− 0.4 ~ − 1.3) | 0.001 | |
Weeks 8 | 29 | 1.83 (0.96) | 30 | 1.58 (0.95) | 28 | 2.44 (1.11) | 0.1 (− 0.4 ~ 0.61.56) | 0.65 | − 1.0 (− 0.6 ~ − 1.4) | < 0.001 | − 1.1 (− 0.6 ~ − 1.6) | < 0.001 | |
Total IgE | 0.14 | ||||||||||||
Weeks 4 | 29 | 146.4 (147.5) | 30 | 171.3 (252.4) | 29 | 278.6 (419.7) | − 19.3 (− 41.8 ~ 3.3) | 0.09 | 12.3 (− 21.0 ~ 45.6) | 0.47 | 31.5 (− 3.9 ~ 67.0) | 0.08 | |
Weeks 8 | 29 | 147.2 (147.7) | 29 | 152.0 (201.7) | 28 | 286.5 (422.5) | 5.9 (− 19.1 ~ 31.0) | 0.64 | 8.9 (− 33.2 ~ 51.0) | 0.68 | 2.9 (− 41.7 ~ 47.5) | 0.90 | |
Sensitivity analysis (primary outcome) | |||||||||||||
BOCF imputation | < 0.01 | ||||||||||||
Weeks 4 | 32 | 5.1 (2.9) | 32 | 5.3 (2.9) | 32 | 8.3 (3.0) | − 0.4 (− 1.9 ~ 1.1) | 0.62 | − 4.1 (− 5.5 ~ − 2.7) | < 0.001 | − 3.7 (− 5.1 ~ − 2.3) | < 0.001 | |
Weeks 8 | 32 | 6.5 (3.0) | 32 | 5.8 (2.9) | 32 | 8.2 (3.8) | 0.5 (− 1.2 ~ 2.2) | 0.56 | − 2.7 (− 4.3 ~ − 1.1) | 0.001 | − 3.2 (− 4.8 ~ − 1.5) | < 0.001 | |
As treated | < 0.01 | ||||||||||||
Weeks 4 | 29 | 4.7 (2.7) | 30 | 5.1 (3.0) | 29 | 8.4 (3.0) | − 0.7 (− 2.2 ~ 0.9) | 0.40 | − 4.8 (− 6.2 ~ − 3.4) | < 0.001 | − 4.1 (− 5.5 ~ − 2.8) | < 0.001 | |
Weeks 8 | 29 | 6.2 (2.9) | 30 | 5.7 (3.0) | 28 | 8.2 (3.9) | 0.4 (− 1.4 ~ 2.2) | 0.65 | − 2.9 (− 4.7 ~ − 1.2) | 0.001 | − 3.3 (− 5.2 ~ − 1.5) | < 0.001 |