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Table 4 Primary and secondary outcomes

From: Acupuncture and herbal moxibustion for the treatment of ‘BiQiu’ (allergic rhinitis symptoms) in a Hong Kong Chinese medicine clinic: a randomized controlled trial

Primary analysis

 

Acupuncture and herbal moxibustion

(N = 32)

Acupuncture

(N = 32)

Waiting list

(N = 32)

Acupuncture and herbal moxibustion vs. acupuncture

Acupuncture and herbal moxibustion vs. waiting list

Acupuncture vs. waiting list

P-value+

n mean (SD)

n mean (SD)

n mean (SD)

β (95% CI)

P-value*

β (95% CI)

P-value*

β (95% CI)

P-value*

TNSS score

            

< 0.01

 Weeks 4

29

4.7 (2.7)

30

5.1 (3.0)

29

8.4 (3.0)

− 0.6 (− 2.1 ~ 0.9)

0.42

− 4.6 (− 6.1 ~ − 3.1)

< 0.001

− 4.0 (− 5.4 ~ − 2.5)

< 0.001

 

 Weeks 8

29

6.2 (2.9)

30

5.7 (3.0)

28

8.2 (3.9)

0.4 (− 1.3 ~ 2.1)

0.67

− 2.8 (− 4.6 ~ − 1.1)

0.002

− 3.2 (− 5.0 ~ − 1.4)

< 0.001

 

RQLQ score

      

< 0.01

 Weeks 4

29

1.56 (0.85)

30

1.71 (1.19)

29

2.32 (0.97)

− 0.3 (− 0.8 ~ 0.2)

0.22

− 1.1 (− 0.7 ~ − 1.6)

< 0.001

− 0.8 (− 0.4 ~ − 1.3)

0.001

 

 Weeks 8

29

1.83 (0.96)

30

1.58 (0.95)

28

2.44 (1.11)

0.1 (− 0.4 ~ 0.61.56)

0.65

− 1.0 (− 0.6 ~ − 1.4)

< 0.001

− 1.1 (− 0.6 ~ − 1.6)

< 0.001

 

Total IgE

      

0.14

 Weeks 4

29

146.4 (147.5)

30

171.3 (252.4)

29

278.6 (419.7)

− 19.3 (− 41.8 ~ 3.3)

0.09

12.3 (− 21.0 ~ 45.6)

0.47

31.5 (− 3.9 ~ 67.0)

0.08

 

 Weeks 8

29

147.2 (147.7)

29

152.0 (201.7)

28

286.5 (422.5)

5.9 (− 19.1 ~ 31.0)

0.64

8.9 (− 33.2 ~ 51.0)

0.68

2.9 (− 41.7 ~ 47.5)

0.90

 

Sensitivity analysis (primary outcome)

 BOCF imputation

            

< 0.01

  Weeks 4

32

5.1 (2.9)

32

5.3 (2.9)

32

8.3 (3.0)

− 0.4 (− 1.9 ~ 1.1)

0.62

− 4.1 (− 5.5 ~ − 2.7)

< 0.001

− 3.7 (− 5.1 ~ − 2.3)

< 0.001

 

  Weeks 8

32

6.5 (3.0)

32

5.8 (2.9)

32

8.2 (3.8)

0.5 (− 1.2 ~ 2.2)

0.56

− 2.7 (− 4.3 ~ − 1.1)

0.001

− 3.2 (− 4.8 ~ − 1.5)

< 0.001

 

 As treated

            

< 0.01

  Weeks 4

29

4.7 (2.7)

30

5.1 (3.0)

29

8.4 (3.0)

− 0.7 (− 2.2 ~ 0.9)

0.40

− 4.8 (− 6.2 ~ − 3.4)

< 0.001

− 4.1 (− 5.5 ~ − 2.8)

< 0.001

 

  Weeks 8

29

6.2 (2.9)

30

5.7 (3.0)

28

8.2 (3.9)

0.4 (− 1.4 ~ 2.2)

0.65

− 2.9 (− 4.7 ~ − 1.2)

0.001

− 3.3 (− 5.2 ~ − 1.5)

< 0.001

 
  1. *GEE model, comparing change from baseline between groups, model: intercept, group, visit, gender, group by visit interaction effect
  2. +GEE model, P-value of group by visit interaction effect